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主要文件

安全信息

G9145

Sigma-Aldrich

[亮氨酸15]-胃泌素 I 人类

≥95% (HPLC)

别名:

[亮氨酸15]-HG-17, LHG-17, [15-亮氨酸]-胃泌素I, 人类十七肽, [18-焦谷氨酸, 32-亮氨酸]-大胃泌素I-(18-34)-肽酰胺,人类, [[亮氨酸15]-小胃泌素 I, [亮氨酸15]-胃泌素 I 十七肽, [亮氨酸15]-胃泌素 I ,人类

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About This Item

经验公式(希尔记法):
C98H126N20O31
CAS号:
分子量:
2080.16
Beilstein:
5227423
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32

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生物来源

human

质量水平

方案

≥95% (HPLC)

表单

powder

技术

cell culture | mammalian: suitable

UniProt登记号

储存温度

−20°C

SMILES字符串

CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C3CCCN3C(=O)CNC(=O)C4CCC(=O)N4)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc5ccc(O)cc5)C(=O)NCC(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc8ccccc8)C(N)=O

InChI

1S/C98H126N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45-46,49-51,61-74,100-101,119H,13,20,25-44,47-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)

InChI key

CMVMLPDUAGUTOC-UHFFFAOYSA-N

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此商品
572330734624544841
氧化铈 IV nanopowder, <25 nm particle size (BET)

544841

氧化铈 IV

form

nanopowder

form

nanopowder

form

powder

form

nanopowder

contains

20 mol % gadolinium as dopant

contains

10 mol % gadolinium as dopant

contains

20 mol % samarium as dopant

contains

-

composition

Ce0.8Gd0.2O2

composition

Ce0.9Gd0.1O2

composition

Sm0.2Ce0.8O1.9

composition

-

reaction suitability

reagent type: catalyst
core: cerium

reaction suitability

reagent type: catalyst
core: cerium

reaction suitability

-

reaction suitability

reagent type: catalyst
core: cerium

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

-

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

一般描述

GAST 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中,GAST 基因定位于 17q21.2。[1]胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体,即前胃泌素。[1]前胃泌素经过裂解和加工产生胃泌素,它对整个胃肠道上皮来说都是营养的。胃泌素对消化系统的生长至关重要,并刺激胃壁细胞产生胃酸。胃泌素通过G 蛋白偶联受体发挥其功能,该受体被称为胆囊收缩素 (CCK) 或 CCK-B 受体 (CCK-BR) 。[2]胃泌素的释放受食物刺激,尤其是蛋白质饮食,并受到非常低的 pH 值的抑制。萎缩性胃炎是幽门螺杆菌感染和长期服用质子泵抑制剂导致的感染,可能导致胃泌素过度表达。胃腺癌显示出高水平的胃泌素。[1]

应用

胃泌素已被用于:
  • 作为培养基补充剂建立肠培养物[3]
  • 作为标准 Dulbeccos ′改良 Eagle 培养基 (DMEM) 的补充剂[4][5]人类小肠培养基[6] 以使crypts生长

生化/生理作用

胃泌素 I 类似物具有完全的生物活性,在水溶液中具有更高的稳定性。 Leu15取代 Met15, 后者很容易被氧化,导致生物活性丧失。

其他说明

从0.1%TFA水溶液中冻干

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品
  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

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    Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy
    Mahe MM, et al.
    Journal of Visualized Experiments, (97), e52483-e52483 (2015)
    D Chen et al.
    Scandinavian journal of gastroenterology, 31(4), 404-410 (1996-04-01)
    Gastrin is thought to stimulate growth of the pancreas via gastrin/cholecystokinin (CCK)-B-type receptors. The aim of the present study was to examine the trophic response of the pancreas to exogenous gastrin or to hypergastrinemia of endogenous origin and to hypogastrinemia
    Human fetal-derived enterospheres provide insights on intestinal development and a novel model to study necrotizing enterocolitis (NEC)
    Senger S, et al.
    Cellular and molecular gastroenterology and hepatology, 5(4), 549-568 (2018)
    Noèlia Téllez et al.
    Endocrinology, 152(7), 2580-2588 (2011-05-12)
    β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell
    J C Reubi et al.
    Cancer research, 57(7), 1377-1386 (1997-04-01)
    Cholecystokinin (CCK)-A and CCK-B/gastrin receptors were evaluated with in vitro receptor autoradiography in 406 human tumors of various origins using a sulfated 125I-labeled CCK decapeptide analogue 125I-(D-Tyr-Gly, Nle28,3l)-CCK 26-33 and 125I-labeled Leu15-gastrin as radioligands. CCK-B/gastrin receptors were found frequently in

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    Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.

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