跳转至内容

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
所有图片(2)

主要文件

SML0788

Sigma-Aldrich

A 83-01

≥98% (HPLC), powder, TGF-β RI kinase inhibitor

别名:

3-（6-甲基-2-吡啶基）-N-苯基-4-（4-喹啉基）-1H-吡唑-1-硫代甲酰胺, A-83-01, A83-01

登录查看公司和协议定价

选择尺寸

100 μL
¥3,875.92

¥3,875.92

预计发货时间2025年7月31日详情

新价格，新优惠！
获取大包装报价
所有图片(2)

选择尺寸

变更视图
100 μL
¥3,875.92

About This Item

经验公式（希尔记法）:
C25H19N5S
CAS号:
909910-43-6
分子量:
421.52
UNSPSC代码:
12352200
NACRES:
NA.77

¥3,875.92

预计发货时间2025年7月31日详情

新价格，新优惠！
获取大包装报价

产品名称

A 83-01, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

S=C([n]2nc(c(c2)c4c5c(ncc4)cccc5)c3nc(ccc3)C)Nc1ccccc1

InChI

1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)

InChI key

HIJMSZGHKQPPJS-UHFFFAOYSA-N

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
C8726C1224C6607
Caspase 8 human ≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine tagged), buffered aqueous solution, ≥1,000 units/mg protein

C1099

Caspase 8 human

Caspase 9 human ≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous solution, >2,000 units/mg protein

C8726

Caspase 9 human

Caspase 3 human ≥85% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous glycerol solution, ≥1.0 units/mg protein

C1224

Caspase 3 human

Caspase 10 human >90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 8,000 units/mg protein (Bradford)

C6607

Caspase 10 human

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

recombinant

expressed in E. coli (C-terminal histidine tagged)

recombinant

expressed in E. coli (C-terminal histidine-tagged)

recombinant

expressed in E. coli (C-terminal histidine-tagged)

recombinant

expressed in E. coli

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

lyophilized powder

Gene Information

human ... CASP8(841)

Gene Information

human ... CASP9(842)

Gene Information

human ... CASP3(836)

Gene Information

human ... CASP10(843)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

一般描述

A-83-01可有效抑制烧伤创面收缩而不影响创面愈合，因为它可抑制转化生长因子-β (TGF-β)诱导的肌成纤维细胞群增加。此外，还可通过抑制动物的上皮间质转化(EMT)来阻止TGF-β1-依赖的癌症转移。[1]

应用

A 83-01已用于：
  • 加入培养基用于分离肿瘤细胞的类器官形成[2]，
  • 加入杜氏改良Eagle培养基/F-12营养混合物(DMEM/F12)中以培养人表皮干细胞(EpSCs)[3]

A 83-01已被用作转化生长因子β激酶1型受体的抑制剂。[4][5]

生化/生理作用

A 83-01是一种TGFβ激酶/激活素受体样激酶（ALK 5）的抑制剂（IC50= 12nM），可阻止Smad2/3的磷酸化并抑制TGFβ诱导的生长。 A 83-01可阻断Smad2的磷酸化并抑制TGF-β诱导的上皮-间质转化。 此外，A 83-01可抑制由TGFβI型受体ALK-5、活化素IB型受体ALK-4、和结节型I受体ALK-7诱导的转录活性。 A-83-01可诱导新生Nkx2.5-eGFP（+）细胞的扩增。
A-83-01是一种TGFβ激酶/激活素受体样激酶(ALK 5)抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000429922
    0000429922
    0000419265
    0000419265
    0000417560

    没有发现合适的版本？

    如果您需要特殊版本，可通过批号或批次号查找具体证书。

    搜索COA

    已有该产品？

    在文件库中查找您最近购买产品的文档。

    访问文档库

    A83-01 inhibits TGF-Β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells.
    Wu Y, et al.
    Breast Cancer Research and Treatment, 163(3), 449-460 (2017)
    Personalized identification of optimal HIPEC perfusion protocol in patient-derived tumor organoid platform
    Forsythe SD, et al.
    Annals of Surgical Oncology, 27, 4950-4960 (2020)
    Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population
    Sun X, et al.
    Bioscience, Biotechnology, and Biochemistry, 78, 1805-1812 (2014)
    The Use of Endometrial Cancer Patient?Derived Organoid Culture for Drug Sensitivity Testing Is Feasible
    Girda E, et al.
    International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, 27(8), 1701-1701 (2017)
    Jin Seok et al.
    Stem cell research & therapy, 11(1), 1-1 (2020-01-05)
    Human placenta-derived mesenchymal stem cells (PD-MSCs) are powerful sources for cell therapy in regenerative medicine. However, a limited lifespan by senescence through mechanisms that are well unknown is the greatest obstacle. In the present study, we first demonstrated the characterization
    查看所有相关文献

    商品

    Human Pancreatic Organoids for Cancer Research Applications

    Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.

    3D类器官培养：用于开发及疾病研究的新体外模型

    可生成组织和干细胞来源3D脑、胃肠道、肺和癌症肿瘤类器官模型的类器官培养产品。

    3D Organoid Culture: New In Vitro Models of Development and Disease

    Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.

    我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

    联系客户支持