product name
SB 202190, ≥98% (HPLC)
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
faintly yellow, to beige
溶解性
DMSO: 10 mg/mL, clear
创始人
GlaxoSmithKline
储存温度
2-8°C
SMILES字符串
Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChI key
QHKYPYXTTXKZST-UHFFFAOYSA-N
基因信息
human ... MAPK14(1432)
一般描述
SB202190可增强NPC1缺陷小鼠神经干细胞的自我更新能力。
应用
SB 202190用于：
- 研究p38丝裂原活化蛋白激酶(MAPK)信号传导对于实现呼肠孤病毒感染的作用
- 作为p38α抑制剂，体内研究其对APC Min/+ 小鼠结肠粘膜组织中腺癌发生发展或进展的作用。
- 作为基底细胞基础培养基组分，培养基底祖细胞。
- 作为正常内膜和内膜肿瘤培养基用于类器官培养。
SB 202190被用于抑制MCF7细胞5、小鼠巨噬细胞6和HepG2细胞的p38活化。7
生化/生理作用
SB 202190是p38 MAP激酶的高选择性、有效的和细胞渗透性抑制剂。SB 202190在活性激酶的ATP口袋内结合（Kd = 38nM，在重组人p38中测量得到），并选择性抑制p38α和β亚型。
特点和优势
该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
法律信息
根据GlaxoSmithKline协议出售，用于研究目的
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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