- Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Nature medicine (2013-03-12)
Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Iván L Csanaky, Curtis D Klaassen, Frank J Gonzalez, Xiaochao Ma
PMID23475203
摘要
Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that co-treatment with RIF and INH causes accumulation of the endogenous hepatotoxin protoporphyrin IX in the liver through PXR-mediated alteration of the heme biosynthesis pathway. These results provide insight into the mechanism of liver injury induced by co-treatment with these compounds and may lead to their safer use in the clinic.
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磷酸酶(碱性) 来源于小牛肠粘膜, suitable for enzyme immunoassay, solution (clear, colorless), ~2500 U/mg protein (~10 mg/ml)
Sigma-Aldrich
碱性磷酸酶 来源于大肠杆菌, ammonium sulfate suspension, 30-90 units/mg protein (modified Warburg-Christian, in glycine buffer)
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碱性磷酸酶 来源于大肠杆菌, buffered aqueous glycerol solution, 20-50 units/mg protein (in glycine buffer)
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磷酸酶，碱性虾, ≥900 DEA units/mL, buffered aqueous glycerol solution, recombinant, expressed in proprietary host