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等级
analytical standard
质量水平
方案
≥99% (TLC)
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
171-173 °C (lit.)
荧光
λex 360 nm; λem 450 nm (thiol adduct)
抗生素抗菌谱
mycobacteria
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
NNC(=O)c1ccncc1
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此商品 | 88597 | H1009 | 18304 |
|---|---|---|---|
| grade for inorganic trace analysis, for ultratrace analysis | grade - | grade - | grade - |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form liquid | form solution | form liquid | form - |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| anion traces bromide (Br-): ≤10 μg/kg, fluoride (F-): ≤1000 μg/kg, phosphate (PO43-): ≤25 μg/kg, chloride (Cl-): ≤25 μg/kg, sulfate (SO42-): ≤50 μg/kg, nitrate (NO3-): ≤250 μg/kg | anion traces - | anion traces - | anion traces - |
应用
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生化/生理作用
针对结核菌的抗生素，抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性，在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。
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警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ram Shankar Upadhayaya et al.
European journal of medicinal chemistry, 45(5), 1854-1867 (2010-02-09)
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at
Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study
Han DC, et al.
Clinical Orthopaedics and Related Research, 471(7), 2400-2406 (2013)
Chang Dong Han et al.
Clinical orthopaedics and related research, 471(7), 2400-2406 (2013-03-19)
Antibiotic-loaded bone cement (ALBC) has been used in serious cases of musculoskeletal tuberculosis, but the type and amount of antibiotic that should be used in ALBC have not been determined. We therefore determined the (1) elution characteristics and (2) antimycobacterial
A fresh look at the mechanism of isoniazid-induced hepatotoxicity.
I G Metushi et al.
Clinical pharmacology and therapeutics, 89(6), 911-914 (2011-03-18)
Molebogeng X Rangaka et al.
Lancet (London, England), 384(9944), 682-690 (2014-05-20)
Antiretroviral therapy reduces the risk of tuberculosis, but tuberculosis is more common in people with HIV than in people without HIV. We aimed to assess the effect of isoniazid preventive therapy on the risk of tuberculosis in people infected with
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