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Merck
CN
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文件

1672206

USP

托吡酯

United States Pharmacopeia (USP) Reference Standard

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别名:
2,3: 双-4,5-O-（1-甲基亚乙基）-36--D -吡喃果糖氨基磺酸酯, McN 4853, RWJ 17021, 妥泰
经验公式（希尔记法）:
C12H21NO8S
CAS号:
97240-79-4
分子量:
339.36
MDL编号:
MFCD00865320
UNSPSC代码:
41116107
PubChem化学物质编号:
329751353
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

topiramate

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

NS(OC[C@]12[C@](OC(C)(C)O2)([H])[C@@]3([H])[C@@](OC(C)(C)O3)([H])CO1)(=O)=O

InChI

1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1

InChI key

KJADKKWYZYXHBB-XBWDGYHZSA-N

基因信息

human ... CA2(760) , CA4(762) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Topiramate USP Reference standard reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard and system suitability solution during the assay, performance test, and impurity analysis by using liquid chromatography coupled with UV detectors in accordance with the given below monographs of United States Pharmacopeia (USP):

  • Topiramate
  • Topiramate Capsules
  • Topiramate Tablets
  • Topiramate Compounded Oral Suspension

生化/生理作用

红藻氨酸 GluR5 受体拮抗剂；抗惊厥药。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Topiramate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 34(5), 4434-4434 (2020)
Topiramate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(6), 4429-4429 (2020)
Topiramate Compounded Oral Suspension
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(4), 4436-4436 (2014)
Topiramate Capsules
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(1), 4432-4432 (2020)
Mattias Linde et al.
The Cochrane database of systematic reviews, 6(6), CD010610-CD010610 (2013-06-26)
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an
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