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Merck
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GABRB3

gamma-aminobutyric acid (GABA) A receptor, beta 3

别名:
ECA5
物种:
UniProtKB ID:
基因ID:
  • Human(2562) Summary: This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
  • Mouse(14402) gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
  • Rat(24922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Zebrafish(566922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • chicken(396290) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Horse(100050803) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • cow(529593) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • dog(606913) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • sheep(101114905) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic cat(100286790) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic guinea pig(100731340) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • naked mole-rat(101711687) gamma-aminobutyric acid (GABA) A receptor, beta 3

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Small Molecule - Agonist

货号
说明
物种
加波沙朵 盐酸盐, solid, ≥98% (HPLC),
物种
human
蝇蕈醇 氢溴酸盐, ≥98% (HPLC), solid,
物种
human
Piperidine-4-sulfonic acid, ,
物种
human
γ-氨基丁酸, ≥99%,
物种
human, rat
2-溴-2-氯-1,1,1-三氟乙烷, ≥99%,
物种
human

Small Molecule - Allosteric Modulator

货号
说明
物种
Etazolate hydrochloride, solid,
物种
human
丙泊酚, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
普鲁泊福, United States Pharmacopeia (USP) Reference Standard,
物种
human
丙泊酚标准液 CRM 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物种
human
普鲁泊福, European Pharmacopoeia (EP) Reference Standard,
物种
human

Small Molecule - Antagonist

货号
说明
物种
SR-95531, ≥98% (HPLC), powder,
物种
human
Flumazenil, United States Pharmacopeia (USP) Reference Standard,
物种
human
Ganaxolone, ≥98% (HPLC), solid,
物种
human, mouse
丙泊酚, 97%,
物种
human
γ-氨基丁酸, ≥99%,
物种
human, rat

Antibodies

货号
说明
物种反应性
应用
Anti-GABRB3 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
应用
immunohistochemistry
western blot
Monoclonal Anti-GABRB3 antibody produced in mouse, clone S87-25, 1 mg/mL, purified immunoglobulin,
物种反应性
human, mouse, rat
应用
immunocytochemistry
western blot
Anti-GABRB3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
canine, human, mouse, rat
应用
ELISA
immunohistochemistry

Small Molecule - Inhibitor

货号
说明
物种
Etazolate hydrochloride, solid,
物种
human
NO-711 hydrochloride, ≥98% (HPLC),
物种
human
(±)-Vigabatrin, ,
物种
human
丙泊酚, 97%,
物种
human
托吡酯, United States Pharmacopeia (USP) Reference Standard,
物种
human

Small Molecule - Ligand

货号
说明
物种
2-溴-2-氯-1,1,1-三氟乙烷, ≥99%,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human GABRB3,
物种
human