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Merck
CN

N142

NO-711 hydrochloride

≥98% (HPLC), GABA uptake inhibitor, powder

别名:

1-[2-[[(Diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride hydrochloride, NNC-711 hydrochloride

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关于此项目

经验公式(希尔记法):
C21H22N2O3 · HCl
化学文摘社编号:
分子量:
386.87
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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产品名称

NO-711 hydrochloride, ≥98% (HPLC)

SMILES string

Cl[H].OC(=O)C1=CCCN(CCO\N=C(/c2ccccc2)c3ccccc3)C1

InChI

1S/C21H22N2O3.ClH/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18;/h1-6,8-12H,7,13-16H2,(H,24,25);1H

InChI key

YZYRTEYMUTWJPL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

solubility

H2O: 10 mg/mL at 60 °C

Quality Level

Application

NO-711 hydrochloride is suitable for use as γ-aminobutyric acid (GABA) transporter-1 (GAT-1) antagonists or GABA uptake inhibitor.

Biochem/physiol Actions

NO-711 is a potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.
NO-711 is a potent and selective GABA uptake inhibitor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Photosensitive

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Mateo Vélez-Fort et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(20), 6921-6929 (2010-05-21)
NG2 cells, oligodendrocyte precursors, play a critical role in myelination during postnatal brain maturation, but a pool of these precursors is maintained in the adult and recruited to lesions in demyelinating diseases. NG2 cells in immature animals have recently been
Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
Santhakumar V, et al.
Neuroscience, 167(3), 644-655 (2010)
E B Nielsen et al.
European journal of pharmacology, 196(3), 257-266 (1991-04-24)
Tiagabine (NO-328) (R(-)-N-[4,4-bis(3-methylthien-2-yl)but-3-enyl]nipecotic acid, hydrochloride) is a new centrally acting GABA uptake inhibitor. The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound. The sedative actions of
Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice
Sugimura M, et al.
Pharmacology, Biochemistry, and Behavior, 72(1-2), 111-116 (2002)
Sampsa T Sipilä et al.
The European journal of neuroscience, 25(3), 717-722 (2007-02-15)
Tonic activation of GABA(A) receptors takes place before the development of functional synapses in cortical structures. We studied whether inefficient GABA uptake might explain the presence of a tonic GABA(A)-mediated current (I(GABA-A)) in early postnatal hippocampal pyramidal neurons. The data

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