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安全信息

UC429

Sigma-Aldrich

Midazolam hydrochloride

solid

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别名:
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
经验公式（希尔记法）:
C18H13ClFN3 · HCl
CAS号:
59467-96-8
分子量:
362.23
EC 号:
261-776-6
MDL编号:
MFCD00864445
UNSPSC代码:
12161501
PubChem化学物质编号:
24724654

形式

solid

药品控制

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

颜色

white to off-white

溶解性

H2O: soluble at least 1 mg/mL

储存温度

2-8°C

SMILES字符串

Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3

InChI key

DDLIGBOFAVUZHB-UHFFFAOYSA-N

基因信息

human ... ABCB1(5243) , CYP3A4(1576) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Gabbr1(81657) , Gabra1(29705)

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应用

Midazolam has been used as an anesthetic for surgical experiments in rats. This anesthetic has also been used in rats to study the interactions between midazolam and bupivacaine.

生化/生理作用

Sedative/hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site; CYP3A4 substrate.

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

制备说明

Midazolam hydrochloride is soluble in water to at least 1 mg/ml. Product solutions should be protected from light.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Natalie L Trevaskis et al.
The Journal of pharmacology and experimental therapeutics, 316(2), 881-891 (2005-10-27)
The influence of the size and turnover kinetics of the enterocyte-based lymph lipid precursor pool (LLPP) on intestinal lymphatic drug transport has been examined. Mesenteric lymph duct-cannulated rats were infused intraduodenally with low (2-5 mg/h) or high (20 mg/h) lipid-dose
D de Wit et al.
Cancer chemotherapy and pharmacology, 73(1), 87-96 (2013-10-24)
Patients treated with sunitinib show substantial inter-patient variability in drug exposure (~30-40 %), which is largely unexplained. Since sunitinib is metabolized by cytochrome P450(CYP)3A4, variability in the activity of this enzyme may explain a considerable proportion of this inter-patient variability.
Eduardo Mekitarian Filho et al.
The Journal of pediatrics, 163(4), 1217-1219 (2013-07-03)
This pilot study introduces the aerosolized route for midazolam as an option for infant and pediatric sedation for computed tomography imaging. This technique produced predictable and effective sedation for quality computed tomography imaging studies with minimal artifact and no significant
Tomoki Nishiyama et al.
Anesthesia and analgesia, 96(5), 1386-1391 (2003-04-23)
Epidurally administered midazolam can potentiate analgesia by epidural bupivacaine. However, whether this effect is synergistic or additive is not known. In this study, we investigated the spinally-mediated analgesic interaction between midazolam and bupivacaine by using the tail-flick and formalin tests
U Khanderia et al.
Clinical pharmacy, 6(7), 533-547 (1987-07-01)
The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, dosage, and cost and availability of midazolam hydrochloride are reviewed. The anxiolytic, sedative, hypnotic, anticonvulsant, muscle-relaxant, and amnesic properties of midazolam are similar to those of other injectable benzodiazepines. Midazolam
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