所有图片(1)
别名:
4,5,6,7-四氢异噁唑[5,4-c]吡啶-3-醇 盐酸盐, THIP 盐酸盐
经验公式（希尔记法）:
C6H8N2O2 · HCl
CAS号:
分子量:
176.60
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
desiccated
颜色
white
溶解性
ethanol: 0.91 mg/mL
H2O: 20 mg/mL
SMILES字符串
Cl[H].Oc1noc2CNCCc12
InChI
1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
InChI key
ZDZDSZQYRBZPNN-UHFFFAOYSA-N
基因信息
human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)
一般描述
加波沙朵，也称为4,5,6,7-四氢异恶唑并（5,4-c）吡啶-3-醇（THIP），是一种GABA位点激动剂。它对突触外高亲和力GABAA受体的δ 亚基具有很强的亲和力。 加波沙朵最初被用于治疗精神分裂症、癫痫、原发性失眠症 和亨廷顿病。它很容易穿过血脑屏障，并迅速被人体吸收。
应用
盐酸加波沙朵已被用于细胞迁移和侵袭测定以评估肝癌细胞的迁移。
生化/生理作用
GABAA 受体激动剂。
注意
光敏
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
GABA and Sleep: Molecular, Functional and Clinical Aspects (2010)
GABA Site Agonist Gaboxadol Induces Addiction-Predicting Persistent Changes in Ventral Tegmental Area Dopamine Neurons But Is Not Rewarding in Mice or Baboons
Vashchinkina E, et al.
The Journal of Neuroscience, 32(15), 5310-5320 (2012)
TEXTBOOK OF GERIATRIC MEDICINE INTERNATIONAL (2011)
Vanessa M Hill et al.
PLoS biology, 16(7), e2005206-e2005206 (2018-07-13)
Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into
M Lancel
Sleep, 22(1), 33-42 (1999-02-16)
This paper reviews the sleep effects of systemically administered agonistic modulators of GABAA receptors, including barbiturates, benzodiazepines, zolpidem, zopiclone and neuroactive steroids, and the selective GABAA agonists muscimol and THIP. To assess the involvement of GABAA receptors in the physiologic
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