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CN
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文件

安全信息

C4024

Sigma-Aldrich

卡马西平

powder

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别名:
5H-二苯并[b,f]氮杂-5-甲酰胺
经验公式（希尔记法）:
C15H12N2O
CAS号:
298-46-4
分子量:
236.27
EC 号:
206-062-7
MDL编号:
MFCD00005073
UNSPSC代码:
12352200
eCl@ss:
34051404
PubChem化学物质编号:
57654002
NACRES:
NA.77

形式

powder

质量水平

100

mp

191-192 °C (lit.)

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL
H2O: insoluble
ethanol: soluble
propylene glycol: soluble

创始人

Novartis

储存温度

2-8°C

SMILES字符串

NC(=O)N1c2ccccc2C=Cc3ccccc13

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

InChI key

FFGPTBGBLSHEPO-UHFFFAOYSA-N

基因信息

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , PRNP(5621) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
rat ... Scn2a1(24766) , Scnn1a(25122) , Scnn1g(24768) , Slc6a1(79212)

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应用

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

生化/生理作用

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.
抗惊厥药；GABAA受体苯二氮卓调节位点的配体。钠离子通道抑制剂。

特点和优势

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3

靶器官

Central nervous system

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration
Clara M, et al.
Water Research, 38(4), 947-954 (2004)
Role of carbamazepine in reducing polypharmacy in epilepsy
Maheshwari MC and Padmini R
Acta Neurologica Scandinavica, 64(1), 22-28 (1981)
Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
Nissinen J and Pitkanen A
Epilepsy Research, 73(2), 181-191 (2007)
K Ogawa et al.
European journal of pain (London, England), 16(7), 994-1004 (2012-02-18)
Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia. However, few studies have evaluated the pharmacological profile of LPA-induced pain. In this study, a LPA-induced pain model was developed and pharmacologically characterized with clinically relevant drugs used for neuropathic
Opeyemi Samson Osuntokun et al.
Toxicology reports, 7, 1592-1596 (2020-12-12)
This study investigated the effects of co-administration of carbamazepine (CBZ) with grape (Vitis vinifera) seed methanolic extract (GSME) on liver toxicity. Thirty-five male rats (145-155 g) were randomized into 5 groups (n = 7) and administered with propylene glycol (PG
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