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Merck
CN
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文件

D126608

Sigma-Aldrich

丙泊酚

97%

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别名:
2,6-双(1-甲基乙基)苯酚, 2,6-双（异丙基）苯酚, 丙泊酚
线性分子式:
[(CH3)2CH]2C6H3OH
CAS号:
2078-54-8
分子量:
178.27
EC 号:
218-206-6
MDL编号:
MFCD00008885
UNSPSC代码:
12352100
PubChem化学物质编号:
24278001
NACRES:
NA.22

蒸汽压

5.6 mmHg ( 100 °C)

质量水平

100

检测方案

97%

形式

liquid

折射率

n20/D 1.514 (lit.)

bp

256 °C/764 mmHg (lit.)

mp

18 °C (lit.)

密度

0.962 g/mL at 25 °C (lit.)

SMILES字符串

CC(C)c1cccc(C(C)C)c1O

InChI

1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3

InChI key

OLBCVFGFOZPWHH-UHFFFAOYSA-N

基因信息

human ... CYP1A2(1544) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706)

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相关类别

一般描述

2,6-二异丙基苯酚（一种强疏水取代苯酚）是一种新型静脉麻醉剂。已研究 2,6-二异丙基苯酚（异丙酚）的抗氧化属性。2,6-二异丙基苯酚是一种有效的静脉注射催眠药，广泛用于麻醉诱导和维持以及重症监护病房的镇静。用于全身麻醉的诱导和维持。

应用

2,6-二异丙基苯酚是研究其对离体大鼠肝线粒体氧化磷酸化作用的合适试剂。是制备双（2,6-二异丙基苯氧基）双（2-甲基-8-喹啉）钛 (IV) 配合物的合适试剂。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

235.4 °F

闪点(°C)

113 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Paul E Marik
Current pharmaceutical design, 10(29), 3639-3649 (2004-12-08)
Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is an oil at room temperature and insoluble in aqueous solution.
C Frenkel et al.
European journal of pharmacology, 208(1), 75-79 (1991-09-12)
Single sodium channels from human brain cortex tissue were incorporated into voltage-clamped planar lipid bilayers in the presence of batrachotoxin and studied with various doses of the new anaesthetic compound propofol (2,6-diisopropylphenol). Propofol was found to depress two major sodium
Configurational rearrangements in cis-M (AA)2X2, cis-M (AA)2XY, and cis-M(AB)2X2 complexes.
Bickley DG and Serpone N.
Inorganic Chemistry, 18(8), 2200-2204 (1979)
Annette P N Kutter et al.
Anesthesia and analgesia, 121(1), 99-107 (2015-03-06)
In critically ill patients with significant pulmonary hypertension (PH), close perioperative cardiovascular monitoring is mandatory, considering the increased morbidity and mortality in this patient group. Although the pulmonary artery catheter is still the standard for the diagnosis of PH, its
M Rigoulet et al.
European journal of biochemistry, 241(1), 280-285 (1996-10-01)
We investigated the effects of 2,6-diisopropylphenol on oxidative phosphorylation of isolated rat liver mitochondria. Diisopropylphenol strongly inhibits state-3 and uncoupled respiratory rates, when glutamate and malate are the substrates, as a direct consequence of the limitation of electron transfer at
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