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Merck
CN
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文件

安全信息

D4000

Sigma-Aldrich

反式-脱氢雄甾酮

≥99%

别名:

3β-羟基-5-雄烯-17-酮, DHEA, 去氢表雄酮, 普拉睾酮, 脱氢异雄酮, 雄素-5-烯-3β-醇-17-酮

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About This Item

经验公式（希尔记法）:
C19H28O2
CAS号:
53-43-0
分子量:
288.42
Beilstein:
2058110
EC 号:
200-175-5
MDL编号:
MFCD00003613
UNSPSC代码:
51111800
PubChem化学物质编号:
24278369
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

检测方案

≥99%

形式

crystalline powder

drug control

Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

mp

149-151 °C (lit.)

溶解性

chloroform: 50 mg/mL, clear, colorless

运输

ambient

储存温度

room temp

SMILES字符串

C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

InChI key

FMGSKLZLMKYGDP-USOAJAOKSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , SERPINA6(866)
rat ... Ar(24208)

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相关类别

生化/生理作用

GABAA 受体的负调节剂。肾上腺分泌的类固醇，具有雌激素和雄激素特性。 它转化为 5-雄烯二醇（一种有效的雌激素）可增强雌激素敏感性乳腺肿瘤的生长和存活率。在高浓度但生理有效的条件下，DHEA 抑制嗜铬细胞祖细胞的增殖并诱导多巴胺能分化。
脱氢雄激素（DHEA）是 GABAA 受体的负调节剂。它是肾上腺分泌的类固醇，具有雌激素和雄激素特性。 脱氢表雄酮（DHEA）转化为 5-雄烯二醇（一种有效的雌激素）可增强雌激素敏感性乳腺肿瘤的生长和存活率。

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361fd

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

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A constant topic reported in the lay press is the effect of sex hormones on athletic performance and their abuse by athletes in their effort to enhance their performance or to either boost or sidestep their hard, protracted, and demanding
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Long-chain acyl-coenzyme A (CoA) synthetase 3 (ACSL3) is an androgen-responsive gene involved in the generation of fatty acyl-CoA esters. ACSL3 is expressed in both androgen-sensitive and castration-resistant prostate cancer (CRPC). However, its role in prostate cancer remains elusive. We overexpressed
Ji Cao et al.
Molecular immunology, 112, 283-290 (2019-06-23)
Dehydroepiandrosterone (DHEA) has anti-inflammatory, anti-oxidant and immune-regulating properties, while the mechanism of DHEA actions remains unclear. The present study aims to investigate the effect and possible mechanism of DHEA on immune function of mice in vivo and in vitro. In
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Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to
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