G002
异去甲基槟榔次碱 盐酸盐
solid
别名:
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
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关于此项目
经验公式（希尔记法）:
C6H9NO2 · HCl
化学文摘社编号:
分子量:
163.60
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
SMILES string
Cl[H].OC(=O)C1=CCNCC1
InChI key
SUWREQRNTXCCBL-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: soluble (refrigerate if not used immediately.), methanol: slightly soluble, neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)
Quality Level
Gene Information
Application
Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
- to study its effects on neuronal activity in rats
- to study its antiallodynic effect in rats
- to study its effects on baroreflex gains in rats
Biochem/physiol Actions
Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Jen-Kun Cheng et al.
Anesthesia and analgesia, 102(1), 182-187 (2005-12-22)
Gabapentin is a novel analgesic whose mechanism of action is not known. We investigated in a postoperative pain model whether adenosine triphosphate (ATP)-sensitive K+ (K(ATP)) channels, N-methyl-d-aspartic acid (NMDA) receptors, and Ca2+ channels are involved in the antiallodynic effect of
Laura Lagostena et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(3), 885-893 (2010-01-22)
GABA, the main inhibitory transmitter in adulthood, early in postnatal development exerts a depolarizing and excitatory action. This effect, which results from a high intracellular chloride concentration ([Cl(-)](i)), promotes neuronal growth and synaptogenesis. During the second postnatal week, the developmental
Kai Y Fan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13718-13728 (2012-10-05)
The symptoms of Parkinson's disease (PD) are related to changes in the frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN). In idiopathic and experimental PD, the GPe and STN
C Silva-Barrat et al.
Brain research, 498(2), 289-298 (1989-10-02)
The interruption of intracortical, chronic GABA infusion is known to give rise to 'GABA withdrawal syndrome' (GWS) consisting of electroencephalographic paroxysmal focal activities, associated with behavioral epileptic signs. Neocortical slices were obtained from rats presenting the GWS (GWS slices), and
Intracapsular technique of transplant nephrectomy
D E Sutherland, et al.
Surgery, Gynecology & Obstetrics, 146(6), 950-952 (1978)
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