SAB5200049
Monoclonal Anti-GABRB3 antibody produced in mouse
clone S87-25, 1 mg/mL, purified immunoglobulin
别名:
Anti-GABA(A) receptor subunit beta3, Anti-GABAAR Beta3, S87-25, Anti-Gabrb3
产品名称
Monoclonal Anti-GABRB3 antibody produced in mouse, clone S87-25, 1 mg/mL, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S87-25, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen predicted mol wt 55 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Gabrb3(14402)
Biochem/physiol Actions
γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).
Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.
Immunogen
Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.
Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Teresa Tavassoli et al.
Molecular autism, 3(1), 6-6 (2012-07-10)
Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene for autism spectrum conditions. In mice, heterozygous Gabrb3 deletion is associated
Paul Hoerbelt et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(8), 3525-3536 (2015-02-27)
Dopamine is a critical neuromodulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates. The present study demonstrates that dopamine (0.1-10 mm) exerts novel, opposing effects on different populations of mammalian (rat) GABAA receptors. Using whole-cell patch-clamp electrophysiology
Chia-Hsiang Chen et al.
PloS one, 9(7), e102227-e102227 (2014-07-16)
GABRB3 encoding the β3 subunit of GABAA receptor has been implicated in multiple neuropsychiatric disorders, including substance abuse. Previous studies reported that SNPs at the 5' regulatory region of GABRB3 could regulate GABRB3 gene expression and associated with childhood absence
J Wagstaff et al.
American journal of human genetics, 49(2), 330-337 (1991-08-11)
Deletions of the proximal long arm of chromosome 15 (bands 15q11q13) are found in the majority of patients with two distinct genetic disorders, Angelman syndrome (AS) and Prader-Willi syndrome (PWS). The deleted regions in the two syndromes, defined cytogenetically and
Marcella Rosa Filézio et al.
DNA and cell biology, 32(3), 125-129 (2013-02-27)
The aim of this study was to evaluate the influence of the γ-aminobutyric acid receptor type A β-3 subunit (GABRB3) polymorphisms in patients with nonsyndromic cleft lip and/or palate (NSCL/P). We carried out a structured case-control analysis of three GABRB3
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