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Merck
CN
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安全信息

F6300

Sigma-Aldrich

Flumazenil

>99% (HPLC), solid, benzodiazepine receptor antagonist

别名:

Ro 15-1788, Ro15-1788

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About This Item

经验公式（希尔记法）:
C15H14FN3O3
CAS号:
78755-81-4
分子量:
303.29
MDL编号:
MFCD00242764
UNSPSC代码:
12352200
PubChem化学物质编号:
24278437
NACRES:
NA.77

product name

Flumazenil, >99% (HPLC), solid

质量水平

100

检测方案

>99% (HPLC)

形式

solid

颜色

white

创始人

Roche

储存温度

2-8°C

SMILES字符串

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

OFBIFZUFASYYRE-UHFFFAOYSA-N

基因信息

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706) , Gabrg1(140674)

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一般描述

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

生化/生理作用

Highly specific benzodiazepine receptor antagonist.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Nahid Amini et al.
Analytical and bioanalytical chemistry, 405(4), 1303-1310 (2012-11-28)
A general method is presented for the identification of radiometabolites in plasma of human and monkey subjects after administration of positron emission tomography (PET) radioligands. The radiometabolites are first produced in vitro, using liver microsomes, subsequently separated using fast radio-liquid
Stina Syvänen et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(12), 1974-1983 (2012-11-13)
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study
Suengmok Cho et al.
Psychopharmacology, 231(14), 2825-2837 (2014-02-04)
In psychopharmacology, researchers have been interested in the hypnotic effects of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant polyphenol, could have potential as a source of novel hypnotic drugs. The effects of phlorotannins and major phlorotannin
Wolf-Dieter Heiss
Annals of the New York Academy of Sciences, 1268, 26-34 (2012-09-22)
An ischemic penumbra has the potential for functional recovery provided that local blood flow can be reestablished, but irreversible damage will develop without sufficient reperfusion, depending on the interaction of severity and duration of ischemia. With acute flows below the
Donna L Seger
Journal of toxicology. Clinical toxicology, 42(2), 209-216 (2004-06-25)
Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined
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