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Merck
CN

SCN7A

sodium channel, voltage-gated, type VII, alpha subunit

Synonyms:
NaG, Nav2.1, Nav2.2, SCN6A
Species:
UniProtKB ID:
Gene ID:
  • Human(6332) Summary: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]
  • Mouse(20272) sodium channel, voltage-gated, type VII, alpha
  • Rat(64155) sodium channel, voltage-gated, type VII, alpha
  • naked mole-rat(101711842) sodium channel, voltage-gated, type VII, alpha subunit
  • domestic guinea pig(100715553) sodium channel, voltage-gated, type VII, alpha subunit
  • dog(488382) sodium channel, voltage-gated, type VII, alpha subunit
  • Horse(100062186) sodium channel, voltage-gated, type VII, alpha subunit
  • cow(507516) sodium channel, voltage-gated, type VII, alpha subunit
  • sheep(101109522) sodium channel, voltage-gated, type VII, alpha subunit
  • domestic cat(101082080) sodium channel, voltage-gated, type VII, alpha subunit

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SCN7A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SCN7A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Blocker

Product Number
Description
Species
Lidocaine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Procaine hydrochloride, ≥97%,
Species
human
Tetracaine hydrochloride, ≥99%,
Species
human
Mexiletine hydrochloride, powder,
Species
human
Lidocaine, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Scn7a,
Species
mouse