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Merck
CN

P9879

普鲁卡因 盐酸盐

≥97% (HPLC), powder, Na⁺ channel blocker

别名:

4-氨基苯甲酸-2-二乙氨乙酯, 奴佛卡因 盐酸盐, 对氨基苯甲酸二乙氨乙酯 盐酸盐

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关于此项目

线性分子式:
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
化学文摘社编号:
51-05-8
分子量:
272.77
NACRES:
NA.77
PubChem Substance ID:
24278665
UNSPSC Code:
12352200
EC Number:
200-077-2
MDL number:
MFCD00013000
Beilstein/REAXYS Number:
3917802

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产品名称

普鲁卡因 盐酸盐, ≥97%

InChI key

HCBIBCJNVBAKAB-UHFFFAOYSA-N

InChI

1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

SMILES string

Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1

assay

≥97%

form

powder

mp

155-156 °C (lit.)

originator

Celgene

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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相关类别

Application

盐酸普鲁卡因已被用作 Krebs Henseleit 缓冲液的组分，用于孵育静息长度的左心室心脏组织。也用作诱导试验中 M9 培养基的诱导剂。

Biochem/physiol Actions

普鲁卡因是一种 Na + 通道阻滞剂，常用作麻醉剂，被认为比可卡因更安全。它也可用作治疗与关节和肌腱相关的疼痛的止痛药。

Features and Benefits

该化合物是基因调控研究的特色产品。 点击此处 ，发现更多特色基因调控产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
该化合物由 Celgene 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000531479
0000531479
BCCP3966
0000504519
0000504519

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J Dudel et al.
Journal of neurophysiology, 81(5), 2386-2397 (1999-05-13)
of quantal end-plate currents of mouse muscle by physostigmine and procaine. Quantal endplate currents (qEPCs) were recorded from hemidiaphragms of mice by means of a macro-patch-clamp electrode. Excitation was blocked with tetrodotoxin, and quantal release was elicited by depolarizing pulses
Ophthalmic Anaesthesia, 5-5 (2002)
Equine Anesthesia E-Book: Monitoring and Emergency Therapy, 215-215 (2002)
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation
Axelsen LN, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 298(6), R1560-R1570 (2010)
Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli
Clarke EJ and Voigt CA
Biotechnology and Bioengineering, 108(3), 666-675 (2011)
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