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Merck
CN

L5647

Sigma-Aldrich

利多卡因 盐酸盐 一水合物

≥99% (HPLC), solid, Na⁺ channel blocker

别名:

2-二乙氨基-N-(2,6-二甲苯基)乙酰胺 盐酸盐 一水合物, 利多卡因 盐酸盐 一水合物, 赛洛卡因 盐酸盐 一水合物

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About This Item

经验公式(希尔记法):
C14H22N2O · HCl · H2O
CAS号:
分子量:
288.81
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

产品名称

利多卡因 盐酸盐 一水合物, solid

表单

solid

质量水平

颜色

white

溶解性

H2O: soluble

SMILES字符串

Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

InChI key

YECIFGHRMFEPJK-UHFFFAOYSA-N

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一般描述

Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.

应用

Lidocaine hydrochloride monohydrate has been used:
  • in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
  • to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
  • For inhibition of glial cells in brain tissue samples.

生化/生理作用

Na+ 通道阻滞剂;IB 类抗心律失常药,在肠胃外给药后迅速吸收
Na+ 通道阻滞剂;IB 类抗心律失常药。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Ion channel recordings on an injection-molded polymer chip
Tanzi S, et al.
Lab on a chip, 13(24), 4784-4793 (2013)
Päivi Ylä-Anttila et al.
Methods in enzymology, 452, 143-164 (2009-02-10)
Electron microscopy remains one of the most accurate methods for the detection of autophagy and quantification of autophagic accumulation. Compared to fluorescence microscopy, the resolution of transmission electron microscopy is superior. In this chapter we describe the fine structure of
Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery
Dubnika A, et al.
Ceramics International, 43(4), 3698-3705 (2017)
Julie I R Labau et al.
Frontiers in pharmacology, 12, 791740-791740 (2022-01-08)
Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different binding
HIV-1 Tat-induced diarrhea evokes an enteric glia-dependent neuroinflammatory response in the central nervous system
Esposito G, et al.
Scientific Reports, 7(1), 7735-7735 (2017)

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