product name
硝苯地平, ≥98% (HPLC), powder
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow
溶解性
DMSO: soluble
ethanol: soluble
创始人
Bayer
储存温度
2-8°C
SMILES字符串
COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OC
InChI
1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChI key
HYIMSNHJOBLJNT-UHFFFAOYSA-N
基因信息
human ... ADORA2A(135) , ADORA3(140) , CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNA2D1(781) , CYP1A2(1544) , KCNH1(3756) , TTR(7276)
mouse ... Cacna1c(12288)
rat ... Adora1(29290) , Adora2a(25369) , Cacna1c(24239) , Cacna1d(29716) , Kcnj1(24521) , Kcnn4(65206) , Tbxas1(24886)
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应用
- 评估其对豚鼠小肠R-型钙通道中肌间神经元钙电流的影响
- 评估L型钙通道阻滞剂对胆碱能和多巴胺能神经元的神经保护作用
- 确定硝苯地平（抗高血压药物）与降糖药共同给药对人脐静脉细胞（HUVEC）的影响
生化/生理作用
特点和优势
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solubility of Product N7634, Nifidipine?
Nifedipine can be dissolved in DMSO at 50 mg/ml1. It is sparingly soluble in absolute ethanol2. Herembert, T. et al., dissolved nifedipine in absolute ethanol (no concentration reported); the maximum ethanol concentration in cultures was 0.2% without any effect of solvent on the cells3. Nifedipine is soluble (g/L, at 20°C) in the following solvents: acetone, 250; methylene chloride, 160; chloroform, 140; ethyl acetate, 50; methanol, 26; ethanol, 17.4 It is practically insoluble in water. The solubilities at 37°C in buffer solutions of different pH values are: pH 4, 0.0058 g/L; pH 7, 0.0056 g/L; pH 9.0, 0.0078 g/L; pH 13, 0.006 g/L1. References: 1. Ali, S.L., Analytical Profiles of Drug Substances, 18, 221, (1989). 2. Martindale, The Extra Pharmacopoeia, 30th ed., 374, (1993). and 3. Herembert, T. et al. Brit. J. Pharmacol., 114, 1703, (1995).
Are there any recommended dosages for Product N7634, Nifidipine, in vivo and in vitro?
Nifedipine is reported to inhibit Ca2+-sensitive K+ channels at 100 μM1. Doses for different animals have been reported2,3. In randomly growing cultures of aortic cells of rats, nifedipine at 10 μM inhibited cell proliferation. References: 1. Thomas-Young, R.J. et al. Biochim. Biophys. Acta, 1146, 81, (1993). 2. Drug Dosages In Laboratory Animals: A Handbook, 3rd ed., Telford Press. and 3. Borchard, R.E. et al. Drug Dosage in Laboratory Animals, A Handbook, Third Edition, p. 315, The Telford Press, (1990).
What is the half life of Product N7634, Nifidipine, in vivo?
After administration by the mouth, the half-life is 2 to 5 hours 1. In plasma, about 92-98% binds to plasma proteins. Nifedipine is completely metabolized. About 70% of a dose is excreted in the urine in 24 hours as metabolites including 5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl) pyridine-3-carboxylic acid; dimethyl 2,6-dimethyl-4-(2-nitrophenyl pyridine-3,5-dicarboxylate and 2-hydroxymethyl-5-methoxycarbonyl-6-methyl-4-(2-nitrophenyl) pyridine-3-carboxylic acid and its lactone derivative. Up to 15% of a dose is eliminated in the feces as metabolites in 4 days 2. References: 1. Martindale, 29th ed., pgs. 1509-1513. 2. Clarke's Isolation and Identification of Drugs., 2nd ed., p. 811.
Are there any recommended conditions that Product N7634, Nifidipine, should be used in?
When exposed to daylight and certain wavelengths of artificial light, nifedipine readily converts to a nitrosophenylpyridine derivative. Exposure to ultra-violet light leads to the formation of a nitrophenylpyridine derivative. Therefore, USP recommends that assays be performed in the dark or under golden fluorescent or other low actinic light. Low actinic glassware should be used1.
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