N5023
去甲二氢愈创木酸
≥90% (HPLC), from Larrea divaricata (creosote bush)
别名:
1,4-双(3,4-二羟苯基)-2,3-二甲基丁烷, 4,4′-(2,3-二甲基四亚甲基)二邻苯二酚, NDGA, 马索罗酚
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线性分子式:
[-CH(CH3)CH2C6H3-1,2-(OH)2]2
化学文摘社编号:
分子量:
302.36
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-903-0
Beilstein/REAXYS Number:
2056826
MDL number:
产品名称
去甲二氢愈创木酸, ≥90% (HPLC), from Larrea divaricata (creosote bush)
InChI key
HCZKYJDFEPMADG-UHFFFAOYSA-N
InChI
1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
SMILES string
CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
biological source
Larrea divaricata (creosote bush)
assay
≥90% (HPLC)
form
crystalline
mp
184-186 °C (lit.)
solubility
ethanol: 50 mg/mL, clear to slightly hazy
Gene Information
human ... ALOX15(246), PTGS1(5742), PTGS2(5743)
mouse ... Alox12(11684)
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Biochem/physiol Actions
脂氧合酶抑制剂；含多酚的邻二羟基（儿茶酚）结构。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Lorena Palacio et al.
Plant science : an international journal of experimental plant biology, 193-194, 1-7 (2012-07-17)
The lignan nordihydroguaiaretic acid (NDGA) and its derivatives existing in Larrea divaricata species show a wide range of pharmacological activities which makes this genus an interesting target to consider the plant in vitro cultivation systems as a feasible alternative source
Ana I Rojo et al.
Free radical biology & medicine, 52(2), 473-487 (2011-12-07)
Defense against oxidative stress is executed by an antioxidant program that is tightly controlled by the transcription factor Nrf2. The stability of Nrf2 involves the interaction of two degradation domains, designated Neh2 and Neh6, with the E3 ubiquitin ligase adaptors
Silvia Arteaga et al.
Journal of ethnopharmacology, 98(3), 231-239 (2005-04-09)
Although controversial, Creosote bush, Larrea tridentata (Sesse and Moc. ex DC) Coville, is used to treat a variety of illnesses including infertility, rheumatism, arthritis, diabetes, gallbladder and kidney stones, pain and inflammation. Recently, it has been used as a nutritional
Irina Daurkin et al.
Cancer research, 71(20), 6400-6409 (2011-09-09)
Renal cell carcinoma (RCC), the most common human kidney cancer, is frequently infiltrated with tumor-associated macrophages (TAM) that can promote malignant progression. Here, we show that TAMs isolated from human RCC produce substantial amounts of the proinflammatory chemokine CCL2 and
Victor Kenyon et al.
Journal of medicinal chemistry, 54(15), 5485-5497 (2011-07-12)
We report the discovery of novel small molecule inhibitors of platelet-type 12-human lipoxygenase, which display nanomolar activity against the purified enzyme, using a quantitative high-throughput screen (qHTS) on a library of 153607 compounds. These compounds also exhibit excellent specificity, >50-fold
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