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Merck
CN

ADORA2A

adenosine A2a receptor

Synonyms:
A2aR, ADORA2, RDC8
Species:
Human ADORA2A (135), Mouse Adora2a (11540), Rat Adora2a (25369), chicken ADORA2A (427705), naked mole-rat Adora2a (101718082), domestic guinea pig Adora2a (100135473), sheep ADORA2A (101112926), cow ADORA2A (617828), Horse ADORA2A (100034039), domestic cat ADORA2A (101080742)
UniProtKB ID:
P29274, B2R7E0
Gene ID:
  • Human(135) Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
  • Mouse(11540) adenosine A2a receptor
  • Rat(25369) adenosine A2a receptor
  • chicken(427705) adenosine A2a receptor
  • naked mole-rat(101718082) adenosine A2a receptor
  • domestic guinea pig(100135473) adenosine A2a receptor
  • sheep(101112926) adenosine A2a receptor
  • cow(617828) adenosine A2a receptor
  • Horse(100034039) adenosine A2a receptor
  • domestic cat(101080742) adenosine A2a receptor
  • dog(403960) adenosine A2a receptor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Product Number
Description
Species
C141
CGS-21680 hydrochloride hydrate, solid,
Species
human
A236
AB-MECA, solid,
Species
human, rat
PHR1138
Adenosine, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
P101
2-Phenylaminoadenosine, >97%, solid,
Species
human, rat
01890
Adenosine, ,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
I7018
3-Isobutyl-1-methylxanthine, BioUltra, ≥99%,
Species
rat
222526
3-Methylxanthine, 98%,
Species
rat
547328
9-Methyladenine, 97%,
Species
rat
H3136
Hematoxylin, certified by the BSC,
Species
rat
H9627
Hematoxylin, ,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
SAB6100012
Anti-AA2AR / Adenosine A2aR Reference Antibody, ,
Species Reactivity
human
Application
AB1559
Anti-Adenosine A2a Receptor Antibody, serum, Chemicon®,
Species Reactivity
bovine, canine, human, pig, rat
Application
ELISA
western blot
05-717
Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2, clone 7F6-G5-A2, Upstate®, from mouse,
Species Reactivity
canine, dog, human, mouse, rabbit, rat
Application
flow cytometry
immunohistochemistry
western blot
AB1559P
Anti-Adenosine A2a Receptor Antibody, Chemicon®, from rabbit,
Species Reactivity
bovine, canine, human, pig
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot
HPA075997
Anti-ADORA2A, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
E114
EHNA hydrochloride, ≥98% (HPLC),
Species
human
D5294
Dilazep dihydrochloride, powder,
Species
human
D5011
5′-Deoxy-5′-(methylthio)adenosine, ,
Species
human, rat, mouse
N2255
S-(4-Nitrobenzyl)-6-thioinosine, ≥98%, solid,
Species
human
282200
Galangin, autophagy inducing flavonoid,
Species
human, rat

Small Molecule - Ligand

Product Number
Description
Species
C4438
2-Chloro-2′-deoxyadenosine, antileukemic,
Species
rat, human
D5385
1,7-Dimethylxanthine, ~98%, solid,
Species
rat, human
C277
Chloro-IB-MECA, solid, ≥98% (HPLC),
Species
human, rat
A9251
Adenosine, ≥99%,
Species
human, rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
F2773
2-Fluoroadenine-9-β-D-arabinofuranoside, DNA synthesis and methylation inhibitor,
Species
rat, human
663115
2-Iodoadenosine, 97%,
Species
human, rat
656402
2-Fluoroadenosine, 97%,
Species
rat, human
C5134
2-Chloroadenosine, ,
Species
human, rat
C277
Chloro-IB-MECA, solid, ≥98% (HPLC),
Species
human, rat

esiRNA

Product Number
Description
Species
EMU035821
MISSION® esiRNA, targeting mouse Adora2a,
Species
mouse
EHU133541
MISSION® esiRNA, targeting human ADORA2A, SPECC1L-ADORA2A,
Species
human