生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 44 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ADORA2A(135)
一般描述
Anti-ADORA2A Antibody detects endogenous levels of total ADORA2A protein.
Adenosine A2a receptor (ADORA2A) is a G protein-coupled receptor. It is highly expressed in the brain. It is located on human chromosome 22q11.23.
免疫原
The antiserum was produced against synthesized peptide derived from human ADORA2A.
Immunogen Range: 321-370
Immunogen Range: 321-370
生化/生理作用
Activation of the adenosine A2a receptor (ADORA2A) prevents T-cell proliferation and production of pro-inflammatory cytokines. It functions in increasing cytosolic cAMP levels. The protein has been associated with stimulation of liver ischemic preconditioning. ADORA2A is also linked to dermal fibrosis and scleroderma.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance
Perez-Aso M, et al.
Purinergic Signaling, 9(4), 573-583 (2013)
Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
Alchera E, et al.
BioMed Research International (2015)
A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease
Dhaenens CM, et al.
Neurobiology of Disease, 35(3), 474-476 (2009)
[Adenosine A2A receptor as a drug target for treatment of sepsis]
Sivak KV, et al.
Molekuliarnaia Biologiia, 50(2), 231-245 (2016)
Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.
Freitag CM
European Child & Adolescent Psychiatry, 19(1), 67-74 (2010)
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