I7018
3-异丁基-1-甲基黄嘌呤
≥99%, Phosphodiesterase inhibitor
别名:
1-甲基-3-异丁基黄嘌呤, 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮, 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮, IBMX
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关于此项目
经验公式（希尔记法）:
C10H14N4O2
化学文摘社编号:
分子量:
222.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
249-259-3
MDL number:
Beilstein/REAXYS Number:
247859
产品名称
3-异丁基-1-甲基黄嘌呤, BioUltra, ≥99%
InChI key
APIXJSLKIYYUKG-UHFFFAOYSA-N
InChI
1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
SMILES string
CC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12
product line
BioUltra
assay
≥99%
impurities
<0.005% Phosphorus (P)
ign. residue
<0.1%
mp
200-201 °C (lit.)
solubility
DMSO: soluble 1 M (with gentle warming)
anion traces
sulfate (SO42-): <0.05%
cation traces
Al: <0.0005%
Ca: <0.005%
Cu: <0.0005%
Fe: <0.005%
K: <0.05%
Mg: <0.005%
NH4+: <0.05%
Na: <0.005%
Pb: <0.001%
Zn: <0.0005%
storage temp.
−20°C
Quality Level
Gene Information
rat ... Adora1(29290), Adora2a(25369)
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Application
3-异丁基-1-甲基黄嘌呤是一种腺苷3′,5′-环但但磷酸磷酸二酯酶 (cAMP PDE)抑制剂，已用于：
- 成脂分化
- 组织培养
- 3T3-L1脂肪前体细胞分化
Biochem/physiol Actions
由IBMX对磷酸二酯酶的抑制而引起的cAMP水平的增加可激活PKA，而引起增殖减少、分化增加并诱导细胞凋亡。IBMX可抑制苯肾上腺素诱导的气道粘膜神经内分泌上皮细胞5-羟色胺释放。（IC50：1.3 μM）。IBMX还可作为一种腺苷受体拮抗剂。其已表现出对神经肌肉接头、GH3细胞和血管平滑肌细胞中离子通道的抑制作用。IBMX可诱导感觉神经元释放储存在细胞内的钙。
由IBMX对磷酸二酯酶的抑制而引起的cAMP水平的增加可激活PKA，而引起增殖减少、分化增加并诱导细胞凋亡。IBMX可抑制苯肾上腺素诱导的气道粘膜神经内分泌上皮细胞5-羟色胺释放（IC50：1.3 μM）。IBMX还可作为一种腺苷受体拮抗剂。其已表现出对神经肌肉接头、GH3细胞和血管平滑肌细胞中离子通道的抑制作用。IBMX可诱导感觉神经元释放储存在细胞内的钙。
Features and Benefits
- ICP法痕量元素检测
- ICP检测痕量硫（硫酸盐形式）和磷（磷酸盐形式）含量
- 离子色谱法检测痕量铵含量
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity
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Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces
Li X, et al.
PLoS ONE, 6(10), e26029-e26029 (2011)
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
David T Manallack et al.
Journal of medicinal chemistry, 48(10), 3449-3462 (2005-05-13)
Ryan D Rose et al.
Theriogenology, 79(1), 142-148 (2012-10-30)
Physical removal of mammalian cumulus-oocyte complexes (COCs) from ovarian follicles results in spontaneous resumption of meiosis, largely because of a decrease in cAMP concentrations, causing asynchrony between cytoplasmic and nuclear maturation and decreased oocyte developmental competence. The aim of this
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