C5134
2-氯腺苷
adenosine A1 receptor agonist, powder
别名:
2-CADO, 2-氯腺嘌呤核苷
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关于此项目
经验公式（希尔记法）:
C10H12ClN5O4
化学文摘社编号:
分子量:
301.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-678-3
MDL number:
Beilstein/REAXYS Number:
43957
Form:
powder
Quality level:
产品名称
2-氯腺苷,
InChI
1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChI key
BIXYYZIIJIXVFW-UUOKFMHZSA-N
SMILES string
Nc1nc(Cl)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
form
powder
Quality Level
Gene Information
human ... ADORA1(134), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
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Application
2-氯腺苷已用于：
- 作为小鼠背侧海马体(DH)和腹侧海马体(VH)腺苷受体(A1R)的激动剂
- 作为人工脑脊液(aCSF)组分，用于海马体切片的电生理实验
- 作为固相萃取-液相色谱-串联质谱法(XLC-MS/MS)的内标，用于定量分析来自轴突裂解物和背根神经节(DRG)神经元的相应代谢物
Biochem/physiol Actions
2-氯腺苷是一种腺苷的类似物。它是腺苷A1受体激动剂。它可能具有抗氧化性能。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sheila Weitzman et al.
Pediatric blood & cancer, 53(7), 1271-1276 (2009-09-05)
A prospective phase II Histiocyte Society study, LCH-S-98, evaluated the efficacy of 2-chlorodeoxyadenosine (2-CdA) monotherapy as salvage therapy in Langerhans cell histiocytosis (LCH). Patients with poor and intermediate risk LCH not responsive to initial therapy and patients with low-risk chronic
Effect of locally infused 2-chloroadenosine, an A1 receptor agonist, on spontaneous and evoked dopamine release in rat neostriatum
Ballarin M, et al.
Neuroscience Letters, 185(1), 29-32 (1995)
2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat
de Mendoncca A and Ribeiro J A
Neuroscience Letters, 118(1), 107-111 (1990)
Léna Borbouse et al.
American journal of physiology. Heart and circulatory physiology, 297(5), H1629-H1637 (2009-09-15)
The role of large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in regulation of coronary microvascular function is widely appreciated, but molecular and functional changes underlying the deleterious influence of metabolic syndrome (MetS) have not been determined. Male Ossabaw miniature swine consumed for
David Tandio et al.
Scientific reports, 9(1), 13555-13555 (2019-09-21)
Adenosine has been reported to be transported by equilibrative nucleoside transporter 4 (ENT4), encoded by the SLC29A4 gene, in an acidic pH-dependent manner. This makes hENT4 of interest as a therapeutic target in acidic pathologies where adenosine is protective (e.g.
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