形式
powder
质量水平
SMILES字符串
Nc1nc(Cl)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
InChI
1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChI key
BIXYYZIIJIXVFW-UUOKFMHZSA-N
基因信息
human ... ADORA1(134) , ADORA3(140)
rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)
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应用
2-氯腺苷已用于：
- 作为小鼠背侧海马体(DH)和腹侧海马体(VH)腺苷受体(A1R)的激动剂
- 作为人工脑脊液(aCSF)组分，用于海马体切片的电生理实验
- 作为固相萃取-液相色谱-串联质谱法(XLC-MS/MS)的内标，用于定量分析来自轴突裂解物和背根神经节(DRG)神经元的相应代谢物
生化/生理作用
2-氯腺苷是一种腺苷的类似物。它是腺苷A1受体激动剂。它可能具有抗氧化性能。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat
de Mendoncca A and Ribeiro J A
Neuroscience Letters, 118(1), 107-111 (1990)
Effect of locally infused 2-chloroadenosine, an A1 receptor agonist, on spontaneous and evoked dopamine release in rat neostriatum
Ballarin M, et al.
Neuroscience Letters, 185(1), 29-32 (1995)
Sheila Weitzman et al.
Pediatric blood & cancer, 53(7), 1271-1276 (2009-09-05)
A prospective phase II Histiocyte Society study, LCH-S-98, evaluated the efficacy of 2-chlorodeoxyadenosine (2-CdA) monotherapy as salvage therapy in Langerhans cell histiocytosis (LCH). Patients with poor and intermediate risk LCH not responsive to initial therapy and patients with low-risk chronic
Javier Díaz-Alonso et al.
eLife, 9 (2020-08-25)
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water
Menglong Zeng et al.
Neuron, 104(3), 529-543 (2019-09-08)
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) modulate AMPAR synaptic trafficking and transmission via disc-large (DLG) subfamily of membrane-associated guanylate kinases (MAGUKs). Despite extensive studies, the molecular mechanism governing specific TARP/MAGUK interaction remains elusive. Using stargazin and PSD-95 as the
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