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质量水平
方案
≥97.0% (HPLC)
表单
crystals
杂质
≤2% water
mp
184-186 °C (lit.)
SMILES字符串
CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
InChI
1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
InChI key
HCZKYJDFEPMADG-UHFFFAOYSA-N
基因信息
mouse ... Alox12(11684)
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一般描述
去甲二氢愈创木酸（NDGA）可用作抗氧化剂和活性氧（ROS）的强效清除剂。
应用
去甲二氢愈创木酸可用于：
- 具有高HIV抑制活性的去甲二氢愈创木酸衍生物的合成。
- 作为合成四-O-甲基去甲二氢愈创木酸的起始原料。
生化/生理作用
脂氧合酶抑制剂；含多酚的邻二羟基（儿茶酚）结构。
其他说明
蚕豆脂氧合酶抑制剂
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo
Lambert JD, et al.
Cancer Letters, 171(1), 47-56 (2001)
H.M. Al-Obaidy et al.
Journal of Food Science, 46, 597-597 (1981)
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs.
Floriano-Sanchez E, et al.
Free Radical Research, 40(5), 523-533 (2006)
New nordihydroguaiaretic acid derivatives as anti-HIV agents.
Hwu JR, et al.
Bioorganic & Medicinal Chemistry Letters, 18(6), 1884-1888 (2008)
Ana I Rojo et al.
Free radical biology & medicine, 52(2), 473-487 (2011-12-07)
Defense against oxidative stress is executed by an antioxidant program that is tightly controlled by the transcription factor Nrf2. The stability of Nrf2 involves the interaction of two degradation domains, designated Neh2 and Neh6, with the E3 ubiquitin ligase adaptors
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