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V4629

（±）-维拉帕米 盐酸盐

≥99% (titration), powder, α1-adrenoceptor antagonist

别名:

5-[N-（3，4-二甲氧基苯基乙基）甲胺基]-2-（3，4-二甲氧基苯基）-2-异丙基戊腈α； 盐酸盐

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关于此项目

线性分子式:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
化学文摘社编号:
152-11-4
分子量:
491.06
NACRES:
NA.77
PubChem Substance ID:
24277881
UNSPSC Code:
12352200
EC Number:
205-800-5
MDL number:
MFCD00055208
Beilstein/REAXYS Number:
3647093
Assay:
≥99% (titration)
Form:
powder
Quality level:
100
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产品名称

（±）-维拉帕米 盐酸盐, ≥99% (titration), powder

Quality Level

100

assay

≥99% (titration)

form

powder

color

white

mp

142 °C (dec.) (lit.)

solubility

methanol: 50 mg/mL, ethanol: soluble

SMILES string

Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Application

盐酸维拉帕米已被用于：
  • 抑制受精卵中的钙振荡
  • 阻断钙通道，从而阻断 IL-1β（白细胞介素-1β）的作用，导致膜去极化
  • 研究维拉帕米对 1，3-二亚油酰甘油（DLG）细胞毒性的影响

Biochem/physiol Actions

α1-肾上腺素受体拮抗剂；L型钙通道阻滞剂。
α1-肾上腺素受体拮抗剂；L型钙通道阻滞剂。阻断平滑肌和心肌中的 L 型 Ca2+ 通道，体外诱导人原发性和转移性结肠癌细胞的凋亡。对 PGP 起作用的抗药性逆转剂，如减少肾小管清除地高辛。增加 Pgp 的基础 ATP 酶活性。Cyp3A4 和 CYP2C6 的底物。

Features and Benefits

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面，请点击此处。
该化合物是ADME Tox研究的特色产品。点击此处 ，查看更多ADME Tox精选产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

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pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000087262
0000071366
0000061258
0000056435
0000047619

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全球贸易项目编号

货号GTIN
V4629-1G04061835516421
V4629-10G04061832964324
V4629-5G04061835559466