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If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

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主要文件

AB1779

Sigma-Aldrich

Anti-Brain Derived Neurotrophic Factor Antibody

serum, Chemicon®

别名:

BDNF

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25 G
¥1,660.00
100 G
¥4,180.06

About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

¥1,660.00


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生物来源

rabbit

质量水平

抗体形式

serum

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

human, rat

制造商/商品名称

Chemicon®

技术

immunohistochemistry: suitable
western blot: suitable

UniProt登记号

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PHR1383

Adenine

Adenine ≥99%

A8626

Adenine

Adenine BioReagent, suitable for cell culture

A2786

Adenine

technique(s)

cell culture | plant: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

UV/Vis spectroscopy: suitable

technique(s)

cell culture | mammalian: suitable

assay

≥99%

assay

-

assay

≥99%

assay

≥99%

form

powder

form

-

form

powder

form

powder

application(s)

agriculture

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

solubility

0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

mp

>360 °C (lit.)

mp

>360 °C (lit.)

mp

>360 °C (lit.)

mp

>360 °C (lit.)

特异性

Brain Derived Neurotrophic Factor (BDNF). By dot blot, less than 1% cross-reactivity against NGF, NT3 or NT4.

SPECIES REACTIVITIES: Rat and human. Other species not yet tested. It is likely that the antibody will also work on mouse and porcine due to sequence homology.

免疫原

Recombinant Human Brain Derived Neurotrophic Factor (BDNF).

应用

Detect Brain Derived Neurotrophic Factor using this Anti-Brain Derived Neurotrophic Factor Antibody validated for use in WB, IH.
Immunohistochemistry: 1:1,000 (see suggested protocol).

Immunoblotting:1:1,000; we recommend preparing the BDNF samples for western blot by the method of Katoh-Semba (1997) because BDNF is not easily extracted in standard buffers. Dissected tissues should be homogenized in 10 volumes of 100mM phosphate buffer containing 1mM EDTA, 2M guanidine hydrochloride (pH7.2), and three protease inhibitors, 10mM N-ethylmaleimide, 0.36mM pepstatin, and 1mM PMSF. Homogenates are then sonicated and centrifuged at 46K x g for 30 minutes at 4C.

BIOLOGICAL ACTIVITY: Neutralizes BDNF, but not other neurotrophins.

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

Neuroinflammation & Pain

外形

Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water.

储存及稳定性

Maintain lyophilized material at -20 to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

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    Ryan G Soderquist et al.
    Journal of biomedical materials research. Part A, 91(3), 719-729 (2008-12-03)
    Brain-derived neurotrophic factor (BDNF) was covalently attached to polyethylene glycol (PEG) in order to enhance delivery to the spinal cord via the cerebrospinal fluid (intrathecal administration). By varying reaction conditions, mixtures of BDNF covalently attached to one (primary), two (secondary)
    Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats.
    Miczek, KA; Nikulina, EM; Shimamoto, A; Covington, HE
    The Journal of Neuroscience null
    Fenghua Chen et al.
    The international journal of neuropsychopharmacology, 21(3), 291-304 (2017-12-12)
    Electroconvulsive therapy is a fast-acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections and synaptic remodeling is thought to play a critical role for
    Tom Verhovshek et al.
    Developmental neurobiology, 73(8), 587-598 (2013-03-21)
    We have previously demonstrated that brain-derived neurotrophic factor (BDNF) interacts with testosterone to regulate dendritic morphology of motoneurons in the highly androgen-sensitive spinal nucleus of the bulbocavernosus (SNB). Additionally, in adult male rats testosterone regulates BDNF in SNB motoneurons and
    Jessica Mary Livingston-Thomas et al.
    Acta pharmacologica Sinica, 34(1), 104-112 (2012-10-30)
    Constraint-induced movement therapy (CIMT), which forces use of the impaired arm following unilateral stroke, promotes functional recovery in the clinic but animal models of CIMT have yielded mixed results. The aim of this study is to develop a refined endothelin-1

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