生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
27kDa
种属反应性
horse, rat, rabbit, dog, mouse, human, pig
浓度
0.5 mg - 1 mg/mL
技术
immunoblotting: suitable
immunohistochemistry: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... BDNF(627)
一般描述
脑源性神经营养因子（BDNF）基因定位于人类染色体 11p14.1 上。BDNF是生长因子中神经营养蛋白家族的成员，该 该基因编码前体蛋白proBDNF。成熟的BDNF（mBDNF）是通过proBDNF的翻译后切割合成的。proBDNF 和 mBDNF 在细胞信号传导中都起着至关重要的作用。
免疫原
指向人 BDNF 中间区域的合成肽
应用
兔抗 BDNF 抗体可用于免疫组化和免疫印迹。
生化/生理作用
脑源性神经营养因子（BDNF）参与人类的海马功能和言语情节记忆。因此，BDNF 基因表达的变异会改变这些神经功能。BDNF在血管功能中也起着至关重要的作用，并通过特异性受体原肌球蛋白相关激酶B（TrkB）参与血管生成。它参与了阿尔茨海默′病的发病机制。ProBDNF 与 p75 神经营养因子受体相互作用，导致海马体的长期抑制。
序列
合成肽位于以下区域：EWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEG
外形
在含 0.09% (w/v) 叠氮化钠和 2% 蔗糖的 1x PBS 缓冲液中提供纯化抗体。
免责声明
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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