产品名称
抗- BDNF 前体 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, human, rat
technique(s)
western blot: 1:200 using rat glioma C6 and human neuroblastoma SH-SY5Y cell lines
western blot: 1:400 using recombinant mouse proBDNF
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BDNF(627)
mouse ... Bdnf(12064)
rat ... Bdnf(24225)
Application
成功使用该抗体的应用以及相关的同行评审论文如下所示。
免疫荧光分析（1篇论文）
免疫荧光分析（1篇论文）
Biochem/physiol Actions
脑源性神经营养因子（BDNF）属于分泌蛋白神经营养因子家族。神经营养因子被合成为前神经营养因子（preproneurotrophin ）前体，并被进一步转化为促神经营养因子（proneurotrophin），然后转化为神经营养因子。BDNF在发育中的和成熟的大脑中表达。BDNF的影响是通过与TrkB受体和p75NTR受体结合进行调节。BDNF促进的下游途径包括PI3K、MAPK 和 JAK/STAT。BDNF最重要的作用是调节突触传递和可塑性、蛋白质合成和局部蛋白质磷酸化。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
不会与 pro-NGF、pro-NT-3 或成熟的 BDNF 发生交叉反应。
脑源性神经营养因子（BDNF）基因定位于人类染色体 11p14.1 上。该基因编码前体蛋白proBDNF。成熟的BDNF（mBDNF）是通过proBDNF的翻译后切割合成的。不会与 pro-NGF、pro-NT-3 或成熟的 BDNF 发生交叉反应。
Immunogen
对应于人 BDNF（前体）氨基酸残基 72-88 的多肽。该序列的 16/17 残基在小鼠和大鼠中是相同的。
Physical form
从含有 1％ 牛血清白蛋白和 ≤0.1% 叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
含少量动物源组分生物产品
常规特殊物品
此项目有
Guiping Xu et al.
Translational neuroscience, 13(1), 430-439 (2022-12-24)
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. Esketamine is
Hui Qiao et al.
Brain research, 1663, 29-37 (2017-03-13)
Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays an important role in the structural plasticity induced by depression. Considering the
11p14. 1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Shinawi M, et al.
American Journal of Medical Genetics. Part A, 155(6), 1272-1280 (2011)
Li Duan et al.
PloS one, 8(9), e73768-e73768 (2013-09-17)
While aberrant activation of microglial cells was evidently involved in neuroinflammation and neurotoxicity in the neurodegenerative diseases such as Alzheimer's and Parkinson's disease, objective of study was to address if activated microglias deliver their effect by releasing pro-neurotrophins. By in
Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain-derived neurotrophic factor in APP/PS1 transgenic mice.
Lin R
Molecular Medicine Reports, 13(2), 1611-1617 (2016)
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