生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
mouse, human, rat
技术
western blot: 1:200 using rat glioma C6 and human neuroblastoma SH-SY5Y cell lines
western blot: 1:400 using recombinant mouse proBDNF
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... BDNF(627)
mouse ... Bdnf(12064)
rat ... Bdnf(24225)
一般描述
不会与 pro-NGF、pro-NT-3 或成熟的 BDNF 发生交叉反应。
脑源性神经营养因子（BDNF）基因定位于人类染色体 11p14.1 上。该基因编码前体蛋白proBDNF。成熟的BDNF（mBDNF）是通过proBDNF的翻译后切割合成的。不会与 pro-NGF、pro-NT-3 或成熟的 BDNF 发生交叉反应。
免疫原
对应于人 BDNF（前体）氨基酸残基 72-88 的多肽。该序列的 16/17 残基在小鼠和大鼠中是相同的。
应用
成功使用该抗体的应用以及相关的同行评审论文如下所示。
免疫荧光分析（1篇论文）
免疫荧光分析（1篇论文）
生化/生理作用
脑源性神经营养因子（BDNF）属于分泌蛋白神经营养因子家族。神经营养因子被合成为前神经营养因子（preproneurotrophin ）前体，并被进一步转化为促神经营养因子（proneurotrophin），然后转化为神经营养因子。BDNF在发育中的和成熟的大脑中表达。BDNF的影响是通过与TrkB受体和p75NTR受体结合进行调节。BDNF促进的下游途径包括PI3K、MAPK 和 JAK/STAT。BDNF最重要的作用是调节突触传递和可塑性、蛋白质合成和局部蛋白质磷酸化。
外形
从含有 1％ 牛血清白蛋白和 ≤0.1% 叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
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