推荐产品
药品控制
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
质量水平
溶解性
ethanol: complete 50 mg/mL
创始人
Abbott
SMILES字符串
CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
InChI
1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChI key
IUJDSEJGGMCXSG-UHFFFAOYSA-N
基因信息
human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
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应用
(±)-Thiopental was used to transiently anesthetize rats for in vivo NMR spectroscopy.
生化/生理作用
Thiopental is an anesthetic that decreases cerebral metabolic rate without altering the blood flow or oxygen consumption.
特点和优势
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
B M Jucker et al.
The Journal of biological chemistry, 272(16), 10464-10473 (1997-04-18)
The effects of increased plasma free fatty acids (FFA) on insulin-dependent whole body glucose disposal, skeletal muscle glycolysis, glycogen synthesis, pyruvate versus FFA/ketone oxidation, and glucose 6-phosphate (Glu-6-P) were investigated in the awake rat. A control group (glycerol-infused) and high
Cerebral circulation and metabolism during thiopental anesthesia and hyper-ventilation in man.
E C PIERCE et al.
The Journal of clinical investigation, 41, 1664-1671 (1962-08-01)
Elisabeth Norman et al.
Pediatric research, 73(1), 87-94 (2012-11-07)
Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, as compared with rapid sequence
Anna Rosati et al.
Neurology, 79(24), 2355-2358 (2012-12-01)
To evaluate the efficacy and safety of ketamine (KE) in the management of refractory convulsive status epilepticus (RSE) in children. In November 2009, we started using KE for treating all children consecutively referred for RSE. Clinical and treatment data were
Colleen K Loo et al.
Journal of affective disorders, 142(1-3), 233-240 (2012-08-04)
Preliminary evidence suggests that the use of ketamine during electroconvulsive therapy (ECT) may be neuroprotective against cognitive impairment and have synergistic antidepressant effects. This study tested whether the addition of ketamine reduced cognitive impairment and enhanced efficacy over a course
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