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Sigma-Aldrich

异柠檬脱氢酶 (NADP) 来源于猪心脏

Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein

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别名:
ICDH, IDH, 苏式-Ds-异柠檬酸: NADP+ 氧化还原酶
CAS号:
9028-48-2
EC 号:
1.1.1.42 (BRENDA, IUBMB)
EC 号:
200-289-5
MDL编号:
MFCD00131420
UNSPSC代码:
12352204
NACRES:
NA.54

类型

Type IV

质量水平

200

形式

buffered aqueous glycerol solution

质量

≤ 0.2% of main activity is obtained with NAD as cofactor.

比活

3-20 units/mg protein

组成

Protein biuret

运输

wet ice

储存温度

2-8°C

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应用

异柠檬酸脱氢酶（IDH）已用于：
  • 体外活性测定，用于研究钍对线粒体呼吸途径中柠檬酸循环酶的影响
  • 作为测量温度对烟酰胺二磷酸（NADP）-IDH 活性影响的标准品
  • 异柠檬酸盐含量测定

生化/生理作用

异柠檬酸脱氢酶（IDH）是一种同源二聚酶，参与适应缺氧、组蛋白去甲基化和 DNA 修饰等一些过程。这种酶有三种异构体，如 IDH1、IDH2 和 IDH3。

单位定义

在37℃条件下，当pH为7.4时，一个单位每分钟将1.0 μ摩尔的异柠檬酸盐转化为至α-酮戊二酸。

外形

50%甘油EDTA缓冲盐溶液，pH 6.0

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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