一般描述
IgA 是人体内产生的最丰富的抗体同种型之一。它主要由位于固有层的浆细胞分泌。IgA 有两种亚型，IgA1 和 IgA2 分别主要存在于气道和结肠中。
应用
来自人血清的 IgA 已被用于酶联免疫吸附试验（ELISA），用于检测血液样本中的抗严重急性呼吸综合征冠状病毒 2 型（严重急性呼吸系统综合征冠状病毒-2）刺突受体结合域（RBD）抗体。
纯化的人 IgA 可用于研究其对炎症、病原体消除、抗体依赖性细胞介导的细胞毒性 (ADCC) 调节、吞噬作用调节、嗜酸性粒细胞和嗜碱性粒细胞脱颗粒以及呼吸爆发活性调节等过程的生理和生物学效应。
生化/生理作用
IgA 有助于诱导对各种病毒病原体的防御机制，如轮状病毒、脊髓灰质炎病毒、流感病毒和严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）。它调节炎症性疾病的过度免疫反应。IgA 还具有触发中性粒细胞募集以进行细胞杀伤的潜力。
外形
溶于 0.01 M 磷酸盐缓冲液 (pH 7.4) 中，含有 15 mM 叠氮化钠作为防腐剂。
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Rafael D Melani et al.
medRxiv : the preprint server for health sciences (2021-07-17)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS , a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and
Isabella Quinti et al.
Frontiers in cellular and infection microbiology, 11, 655896-655896 (2021-04-24)
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It
Development of a Duplex Serological Multiplex Assay for the Simultaneous Detection of Epstein-Barr Virus IgA and IgG Antibodies in Nasopharyngeal Carcinoma Patients.
Schieber, et al.
Cancers, 15 (2023)
Andrea Reboldi et al.
Science (New York, N.Y.), 352(6287), aaf4822-aaf4822 (2016-05-14)
Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the
Hans Verkerke et al.
Journal of clinical microbiology, 59(4) (2021-01-21)
Accurate diagnosis of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical for appropriate management of patients with this disease. We examined the possible complementary role of laboratory-developed class-specific clinical serology in assessing SARS-CoV-2 infection in hospitalized patients.
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