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Merck
CN

I2511

IgG 来源于人类血清

reagent grade, ≥95% (HPLC), buffered aqueous solution

别名:

人 IgG

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MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.46
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偶联物

unconjugated

质量水平

等级

reagent grade

方案

≥95% (HPLC)

表单

buffered aqueous solution

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

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一般描述

IgG抗体亚型是免疫系统中含量最高的血清免疫球蛋白。它由B细胞分泌,存在于血液和细胞外液中,可防止细菌、真菌和病毒引起的感染。母体IgG可通过胎盘转移至胎儿,胎盘对新生儿免疫防御感染至关重要。
人IgG是从正常人血清中通过沉淀和凝胶过滤技术纯化得来的。

应用

纯化人IgG已用于:-
  • 作为流式细胞仪的封闭抗体
  • 作为染色质免疫沉淀试验中的阴性对照
  • 免疫沉淀法沉淀人喉表皮样癌细胞中的IgG
  • 作为酶联免疫吸附试验的标准品

生化/生理作用

免疫球蛋白G(IgG)可调节免疫应答,例如吞噬作用,并且还可参与自身免疫疾病的发展。IgG1可调节小鼠的补体结合。

外形

0.01M磷酸盐缓冲盐水溶液,pH 7.4,含有15 mM叠氮化钠

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

高风险级别生物产品--人源产品
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Kentaro Matsuda et al.
The Journal of allergy and clinical immunology, 116(6), 1357-1363 (2005-12-13)
Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen. To determine whether human IgE, in the absence of known specific
In-Kyu Yoon et al.
The American journal of tropical medicine and hygiene, 72(6), 714-718 (2005-06-21)
Volunteers vaccinated with a candidate malaria vaccine containing merozoite surface protein 1(42) (MSP-1(42)) exhibit antibodies to MSP-1(42) that are measured by enzyme-linked immunosorbent assay (ELISA). The purpose of this study was to make a human reference standard for MSP-1(42) antibody
Kah Teong Soh et al.
Current protocols in cytometry, 75, 7-7 (2016-01-09)
Nucleic acid content can be quantified by flow cytometry through the use of intercalating compounds; however, measuring the presence of specific sequences has hitherto been difficult to achieve by this methodology. The primary obstacle to detecting discrete nucleic acid sequences
Sandra S Wright et al.
Journal of pediatric gastroenterology and nutrition, 66(5), 767-772 (2017-12-08)
Elevated granulocyte-macrophage colony-stimulating factor auto-antibodies (GM-CSF Ab) are associated with increased intestinal permeability and stricturing behavior in Crohn disease (CD). We tested for familial association of serum GM-CSF Ab level in CD and ulcerative colitis (UC) families. Serum GM-CSF Ab
Rebeca M Torrente-Rodríguez et al.
PloS one, 12(4), e0175056-e0175056 (2017-04-05)
The first electrochemical immunosensor for the determination of fibroblast growth factor receptor 4 (FGFR4) biomarker is reported in this work. The biosensor involves a sandwich configuration with covalent immobilization of a specific capture antibody onto activated carboxylic-modified magnetic microcarriers (HOOC-MBs)

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