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一般描述
IgG抗体亚型是免疫系统中含量最高的血清免疫球蛋白。它由B细胞分泌，存在于血液和细胞外液中，可防止细菌、真菌和病毒引起的感染。母体IgG可通过胎盘转移至胎儿，胎盘对新生儿免疫防御感染至关重要。
人IgG是从正常人血清中通过沉淀和凝胶过滤技术纯化得来的。
人IgG是从正常人血清中通过沉淀和凝胶过滤技术纯化得来的。
应用
纯化人IgG已用于：-
- 作为流式细胞仪的封闭抗体
- 作为染色质免疫沉淀试验中的阴性对照
- 免疫沉淀法沉淀人喉表皮样癌细胞中的IgG
- 作为酶联免疫吸附试验的标准品
生化/生理作用
免疫球蛋白G（IgG）可调节免疫应答，例如吞噬作用，并且还可参与自身免疫疾病的发展。IgG1可调节小鼠的补体结合。
外形
0.01M磷酸盐缓冲盐水溶液，pH 7.4，含有15 mM叠氮化钠
免责声明
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Kentaro Matsuda et al.
The Journal of allergy and clinical immunology, 116(6), 1357-1363 (2005-12-13)
Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen. To determine whether human IgE, in the absence of known specific
In-Kyu Yoon et al.
The American journal of tropical medicine and hygiene, 72(6), 714-718 (2005-06-21)
Volunteers vaccinated with a candidate malaria vaccine containing merozoite surface protein 1(42) (MSP-1(42)) exhibit antibodies to MSP-1(42) that are measured by enzyme-linked immunosorbent assay (ELISA). The purpose of this study was to make a human reference standard for MSP-1(42) antibody
Kah Teong Soh et al.
Current protocols in cytometry, 75, 7-7 (2016-01-09)
Nucleic acid content can be quantified by flow cytometry through the use of intercalating compounds; however, measuring the presence of specific sequences has hitherto been difficult to achieve by this methodology. The primary obstacle to detecting discrete nucleic acid sequences
Astgik Petrosyan et al.
Nature communications, 10(1), 3656-3656 (2019-08-15)
In this work we model the glomerular filtration barrier, the structure responsible for filtering the blood and preventing the loss of proteins, using human podocytes and glomerular endothelial cells seeded into microfluidic chips. In long-term cultures, cells maintain their morphology
Alberto Sinibaldi et al.
Biosensors, 8(3) (2018-07-26)
Optical biosensors based on one-dimensional photonic crystals sustaining Bloch surface waves are proposed to study antibody interactions and perform affinity studies. The presented approach utilizes two types of different antibodies anchored at the sensitive area of a photonic crystal-based biosensor.
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