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生物来源
bovine submaxillary glands
质量水平
类型
Type I-S
表单
powder
组成
Bound sialic acids, 9-24%
技术
electrophoresis: suitable
UniProt登记号
储存温度
−20°C
基因信息
cow ... BSM(286841)
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一般描述
牛颌下腺粘蛋白由两个牛颌下 BSM 基因编码，存在于唾液中并与空气和食物相互作用。 粘蛋白包含三个主要结构域，即 N 和 C 末端以及糖基化脯氨酸、苏氨酸和丝氨酸（PTS 结构域）中心结构域。唾液酸占粘蛋白分子量的 30%。中心结构域包含多个串联重复序列。
应用
牛颌下腺粘蛋白已用于：
- 粘蛋白的定量测定
- 作为人工泪液溶液的成分
- 作为阴道加德纳氏菌重组唾液酸酶的底物
- 研究来自红海藻羽状翼藻的半乳糖特异性凝集素
- 研究人类子宫内膜腺癌细胞系 (Ishikawa) 分泌的独特粘蛋白样糖蛋白的表征
生化/生理作用
牛颌下腺粘蛋白 (BSM)在高达 85°C的温度下可保持稳定。末端结构域是粘蛋白吸收功能的关键。
粘液中的蛋白质类物质使其具有粘性
联系
类似于 M 4503，但由 Sigma 生产。
底物
神经氨酸苷酶 n底物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Sasi B Yarragudi et al.
Carbohydrate polymers, 163, 216-226 (2017-03-08)
Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and nasal clearance. Recent modelling data indicates that 10μm-sized microparticles
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium
Brookes DM, et al.
British Journal of Pharmacology, 175(12), 2520-2534 (2018)
Identification and characterization of NanH2 and NanH3, enzymes responsible for sialidase activity in the vaginal bacterium Gardnerella vaginalis
Robinson LS, et al.
Test, 294(14), 5230-5245 (2019)
Hayley Thompson et al.
Journal of bacteriology, 191(11), 3623-3628 (2009-03-24)
Sialidase activity is a putative virulence factor of the anaerobic periodontal pathogen Tannerella forsythia, but it is uncertain which genes encode this activity. Characterization of a putative sialidase, SiaHI, by others, indicated that this protein alone may not be responsible
Lindsay R Gabbert et al.
Health security, 16(4), 244-251 (2018-08-11)
Validated procedures for decontamination of laboratory surfaces and equipment are essential to biosafety and biorisk programs at high-containment laboratories. Each high-containment laboratory contains a unique combination of surfaces, procedures, and biological agents that require decontamination methods tailored to specific facility
商品
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