M3895
黏液蛋白 来源于牛颔下腺
Type I-S
别名:
MUC
biological source
bovine submaxillary glands
type
Type I-S
form
powder
composition
Bound sialic acids, 9-24%
technique(s)
electrophoresis: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
cow ... BSM(286841)
General description
牛颌下腺粘蛋白由两个牛颌下 BSM 基因编码，存在于唾液中并与空气和食物相互作用。 粘蛋白包含三个主要结构域，即 N 和 C 末端以及糖基化脯氨酸、苏氨酸和丝氨酸（PTS 结构域）中心结构域。唾液酸占粘蛋白分子量的 30%。中心结构域包含多个串联重复序列。
神经氨酸苷酶 n底物
Application
牛颌下腺粘蛋白已用于：
- 粘蛋白的定量测定
- 作为人工泪液溶液的成分
- 作为阴道加德纳氏菌重组唾液酸酶的底物
- 研究来自红海藻羽状翼藻的半乳糖特异性凝集素
- 研究人类子宫内膜腺癌细胞系 (Ishikawa) 分泌的独特粘蛋白样糖蛋白的表征
Biochem/physiol Actions
牛颌下腺粘蛋白 (BSM)在高达 85°C的温度下可保持稳定。末端结构域是粘蛋白吸收功能的关键。
粘液中的蛋白质类物质使其具有粘性
Other Notes
类似于 M 4503，但由 Sigma 生产。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
此项目有
The central domain of bovine submaxillary mucin consists of over 50 tandem repeats of 329 amino acids: Chromosomal localization of the BSM1 gene and relations to ovine and porcine counterparts
Jiang W, et al.
European Journal of Biochemistry, 267(8), 2208-2217 (2000)
Proteolytic degradation of bovine submaxillary mucin (BSM) and its impact on adsorption and lubrication at a hydrophobic surface
Madsen JB, et al.
Langmuir, 31(30), 8303-8309 (2015)
A H Sampaio et al.
Phytochemistry, 48(5), 765-769 (1998-07-17)
A lectin from the red marine alga Ptilota filicina (PFL) was isolated by affinity chromatography on cross-linked guar gum. PFL agglutinated native and papain-treated human erythrocytes with preference for type O erythrocytes. The lectin was inhibited by galactose and its
Instability and breakup of model tear films
Bhamla MS, et al.
Investigative Ophthalmology & Visual Science, 57(3), 949-958 (2016)
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium
Brookes DM, et al.
British Journal of Pharmacology, 175(12), 2520-2534 (2018)
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