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Merck
CN
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文件

P7295

Supelco

扑米酮

analytical standard

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别名:
2-脱氧苯巴比妥, 5-乙基-5-苯基六氢嘧啶-4,6-二酮
经验公式（希尔记法）:
C12H14N2O2
CAS号:
125-33-7
分子量:
218.25
EC 号:
204-737-0
MDL编号:
MFCD00038662
UNSPSC代码:
41116107
PubChem化学物质编号:
329820263
NACRES:
NA.24

等级

analytical standard

质量水平

100

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

SMILES字符串

CCC1(C(=O)NCNC1=O)c2ccccc2

InChI

1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)

InChI key

DQMZLTXERSFNPB-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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相关类别

一般描述

Primidone is a commonly used antiepileptic and anticonvulsant drug belonging to the class of barbiturates. It is found to be effective in the treatment of partial and generalized seizures.

应用

Primidone may be used as a reference standard for the determination of the analyte in serum samples using high-pressure liquid chromatography.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化/生理作用

抗惊厥药

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H302,H351,H361d

危险分类

Acute Tox. 4 Oral - Carc. 2 - Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
Sullivan MF and McElhatton RP
Toxicology and Applied Pharmacology, 40(2), 365-378 (2006)
Simultaneous measurement of phenobarbital, phenytoin, primidone, ethosuximide, and carbamazepine in serum by high-pressure liquid chromatography.
Kabra MP, et al.
Clinical Chemistry, 23(7), 1284-1288 (1977)
Textbook of Therapeutics: Drug and Disease Management (2006)
Günther Deuschl et al.
The Lancet. Neurology, 10(2), 148-161 (2011-01-25)
Essential tremor is a common movement disorder. Tremor severity and handicap vary widely, but most patients with essential tremor do not receive a diagnosis and hence are never treated. Furthermore, many patients abandon treatment because of side-effects or poor efficacy.
Siyuan Zhao et al.
eLife, 9 (2020-04-29)
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated with intellectual disability and epilepsy;
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