跳转至内容
Merck
CN
  • Altered plasma lysophosphatidylcholines and amides in non-obese and non-diabetic subjects with borderline-to-moderate hypertriglyceridemia: a case-control study.

Altered plasma lysophosphatidylcholines and amides in non-obese and non-diabetic subjects with borderline-to-moderate hypertriglyceridemia: a case-control study.

PloS one (2015-04-10)
Sae Young Lee, Minjoo Kim, Saem Jung, Sang-Hyun Lee, Jong Ho Lee
摘要

Hypertriglyceridemia (HTG) is a risk factor for atherosclerotic cardiovascular disease (CVD). We investigated alterations in plasma metabolites associated with borderline-to-moderate HTG (triglycerides (TG) 150-500 mg/dL). Using UPLC-LTQ-Orbitrap mass spectrometry analysis, the metabolomics profiles of 111 non-diabetic and non-obese individuals with borderline-to-moderate HTG were compared with those of 111 age- and sex-matched controls with normotriglyceridemia (NTG, TG <150 mg/dL). When compared to the NTG control group, the HTG group exhibited higher plasma levels of lysophosphatidylcholines (lysoPCs), including C14:0 (q = 0.001) and C16:0 (q = 1.8E-05), and several amides, including N-ethyldodecanamide (q = 2.9E-05), N-propyldodecanamide (q = 3.5E-05), palmitoleamide (q = 2.9E-06), and palmitic amide (q = 0.019). The metabolomic profiles of the HTG group also exhibited lower plasma levels of cis-4-octenedioic acid (q<1.0E-9) and docosanamide (q = 0.002) compared with those of the NTG controls. LysoPC 16:0 and palmitoleamide emerged as the primary metabolites able to discriminate the HTG group from the NTG group in a partial least-squares discriminant analysis and were positively associated with the fasting triglyceride levels. We identified alterations in lysoPCs, amides, and cis-4-octenedioic acid among non-diabetic and non-obese individuals with borderline-to-moderate HTG. These results provide novel insights into the metabolic alterations that occur in the early metabolic stages of HTG. This information may facilitate the design of early interventions to prevent disease progression.

材料
货号
品牌
产品描述

Sigma-Aldrich
乙腈, suitable for HPLC, gradient grade, ≥99.9%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
甲酸, reagent grade, ≥95%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
甲酸, ACS reagent, ≥96%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, ACS reagent, ≥99.5%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, for HPLC, for UV, ≥99.9% (GC)
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, suitable for HPLC, gradient grade, ≥99.9%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, suitable for HPLC-GC, ≥99.8% (GC)
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, biotech. grade, ≥99.93%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, anhydrous, 99.8%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
甲酸, ≥95%, FCC, FG
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, ReagentPlus®, 99%
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, electronic grade, 99.999% trace metals basis
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
特非那定
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, suitable for DNA synthesis, ≥99.9% (GC)
货号
包装规格
是否有货
价格
数量
Supelco
醋氨酚 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
货号
包装规格
是否有货
价格
数量
Supelco
乙腈, Pharmaceutical Secondary Standard; Certified Reference Material
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, ≥99.5% (GC)
货号
包装规格
是否有货
价格
数量
USP
二类残留溶剂 - 甲醇, United States Pharmacopeia (USP) Reference Standard
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
甲酸 溶液, BioUltra, 1.0 M in H2O
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
利血平, crystallized, ≥99.0% (HPLC)
货号
包装规格
是否有货
价格
数量
Supelco
乙腈, analytical standard
货号
包装规格
是否有货
价格
数量
Supelco
磺胺地索辛, VETRANAL®, analytical standard
货号
包装规格
是否有货
价格
数量
Supelco
残留溶剂-乙腈, Pharmaceutical Secondary Standard; Certified Reference Material
货号
包装规格
是否有货
价格
数量
Supelco
磺胺地索辛, Pharmaceutical Secondary Standard; Certified Reference Material
货号
包装规格
是否有货
价格
数量
Supelco
磺胺地索辛, 98.0-102.0%
货号
包装规格
是否有货
价格
数量
特非那定, European Pharmacopoeia (EP) Reference Standard
货号
包装规格
是否有货
价格
数量
磺胺地索辛, European Pharmacopoeia (EP) Reference Standard
货号
包装规格
是否有货
价格
数量
Sigma-Aldrich
乙腈, Preparateur, ≥99.9% (GC), One-time steel-plastic (SP) drum
货号
包装规格
是否有货
价格
数量