推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
SNAP-N-SPIKE®, SNAP-N-SHOOT®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
single component solution
储存温度
−20°C
SMILES字符串
CC(=O)Nc1ccc(O)cc1
InChI
1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
InChI key
RZVAJINKPMORJF-UHFFFAOYSA-N
基因信息
human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)
一般描述
分析标准品适合用作校准器或对照品中的原材料，用于从法医分析和临床毒理学到P450研究和其他药物研究等各种LC/MS或GC/MS应用。对乙酰氨基酚，或称扑热息痛，是一种常见的非处方COX 抑制剂药物，用于缓解疼痛和退烧。
这种物质被列入EU第10/2011号法规中用于与食品接触的塑料的正面清单。在此查找10/2011中列出的化合物的所有可用参考材料
这种物质被列入EU第10/2011号法规中用于与食品接触的塑料的正面清单。在此查找10/2011中列出的化合物的所有可用参考材料
应用
- 强化水溶液中对乙酰氨基酚的去除情况：该研究以来源于金桔皮的生物炭为沸石咪唑骨架-67（ZIF-67）的载体，以此来改善过乙酸活化引起的对乙酰氨基酚的去除，研究展示了一种创新的废水处理方法（Nguyen et al., 2024）。
- 用于对乙酰氨基酚降解的钴掺杂生物炭：关于Cu/N共掺杂生物炭激活的过一硫酸盐（PMS）的研究揭示了对乙酰氨基酚的非自由基降解途径，该途径以单线态氧和电子转移为主，为可持续的环境清理技术提供了见解（Wu et al., 2024）。
- 包括对乙酰氨基酚在内的药物的生物降解： 一项关于药物和个人护理产品厌氧共代谢生物降解的研究强调，甘油发酵是一种驱动机制，该研究为管理对乙酰氨基酚等物质的环境污染提供了一种可行的策略（Carneiro et al., 2024）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
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