S7007
磺胺地索辛
98.0-102.0%
别名:
4-氨基-N-(2,6-二甲氧-4-嘧啶基)苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C12H14N4O4S
化学文摘社编号:
分子量:
310.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
204-523-7
Beilstein/REAXYS Number:
306856
MDL number:
产品名称
磺胺地索辛, 98.0-102.0%
InChI
1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI key
ZZORFUFYDOWNEF-UHFFFAOYSA-N
SMILES string
COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1
assay
98.0-102.0%
form
powder
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
application(s)
forensics and toxicology
pharmaceutical (small molecule)
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
Quality Level
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Application
有关适用仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务部门。
Biochem/physiol Actions
通过抑制二氢叶酸合成酶阻断二氢叶酸合成的磺胺类抗生素。
作用方式：在原核生物中抑制叶酸合成。
抗菌谱：革兰氏阳性菌、革兰氏阴性菌、衣原体
抗性机理：二氢叶酸合成酶或叶酸合成替代路径的改变。
作用方式：在原核生物中抑制叶酸合成。
抗菌谱：革兰氏阳性菌、革兰氏阴性菌、衣原体
抗性机理：二氢叶酸合成酶或叶酸合成替代路径的改变。
General description
化学结构：磺胺
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Annie von Eyken et al.
Journal of the American Society for Mass Spectrometry, 30(5), 765-777 (2019-03-17)
Non-targeted screening (e.g., suspected-target) is emerging as an attractive tool to investigate the occurrence of contaminants in food. The sample preparation and instrument analysis steps are known to influence the identification of analytes with non-targeted workflows, especially for complex matrices.
Alexandra Dheilly et al.
Antimicrobial agents and chemotherapy, 56(1), 189-196 (2011-10-12)
An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated with rifampin-resistant
Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups.
Silvia Gazzin et al.
Pediatric research, 71(6), 653-660 (2012-02-18)
Few data exist on regional brain bilirubin content in the neonatal period when acute bilirubin-induced neurologic damage (BIND) may occur, and no information is available on regional brain expression of cytochrome P450 monooxygenases (Cyps) that oxidize bilirubin. Bilirubin content was
Lou Ann Tom et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 909, 61-64 (2012-11-17)
Four non-covalently prepared molecularly imprinted polymers (MIPs) for sulfadimethoxine (SDM) were prepared using different ratios of SDM template, methacrylic acid monomer, and ethylene glycol dimethacrylate cross-linker. The imprinting factor (IF) was calculated by comparing the retention of SDM on the
Dan Liu et al.
Chemical & pharmaceutical bulletin, 59(1), 63-71 (2011-01-08)
Recently, dendrimers have been widely used in medical applications such as drug delivery and gene transfection. In this study, a pH-sensitive diblock copolymer of poly(methacryloyl sulfadimethoxine) (PSD) and polyethylene glycol (PEG) modified by lactose (LA-PEG-b-PSD) was synthesized. The pK(a) value
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