检测方案
≥99.0% (HPLC)
形式
solid
旋光性
[α]20/D −123±3°, c = 1% in chloroform
质量
crystallized
mp
~265 °C (dec.)
SMILES字符串
CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
InChI
1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChI key
QEVHRUUCFGRFIF-MDEJGZGSSA-N
基因信息
human ... SLC18A2(6571)
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一般描述
利血平是一种吲哚生物碱,它不可逆地结合囊泡单胺转运蛋白VMAT1和VMAT2。它是一种可用于治疗系统性高血压的抗交感神经药物。
应用
利血平已被用作性能研究中的测试化学物质。
生化/生理作用
利血平用于治疗妊娠期高血压(hypertensive pregnancy difficulties)。这种药物也是一种抗精神病药和降压药,可调节高血压。
抑制儿茶酚胺和血清素的囊泡摄取。
警示用语:
Danger
危险分类
Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
靶器官
Central nervous system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
Heart and circulatory system drugs and diuretics
Drugs During Pregnancy and Lactation, 193-236 (2007)
Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium
Reproductive Toxicology, 70, 116-125 (2017)
What All Should Know about Plant Drugs
Essentials of Biochemistry for Medical Students, 35-61 (2015)
Scientific reports, 10(1), 12323-12323 (2020-07-25)
In this study a robust, whole organism screening based on Caenorhabditis elegans is presented for the discovery of natural products (NP) with beneficial effects against obesity and age-related diseases. Several parameters of the elaborated workflow were optimized to be adapted
Antimicrobial agents and chemotherapy, 53(6), 2463-2468 (2009-04-15)
Recent studies have suggested that exposure to fluoroquinolones represents a risk factor for the development of Clostridium difficile infections and that the acquisition of resistance to the newer fluoroquinolones is the major reason facilitating wide dissemination. In particular, moxifloxacin (MX)
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