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Merck
CN

83580

利血平

≥99.0% (HPLC), serotonin uptake inhibitor, solid

别名:

(3β, 16β, 17α, 18β, 20α)-11,17-二甲氧基-18-[(3,4,5-三甲氧基苯甲酰基)氧基]育亨烷-16-羧酸甲酯

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关于此项目

经验公式（希尔记法）:
C33H40N2O9
化学文摘社编号:
50-55-5
分子量:
608.68
NACRES:
NA.77
PubChem Substance ID:
329769078
UNSPSC Code:
12352200
EC Number:
200-047-9
MDL number:
MFCD00005091
Beilstein/REAXYS Number:
102014
Assay:
≥99.0% (HPLC)
Form:
solid

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产品名称

利血平, crystallized, ≥99.0% (HPLC)

InChI key

QEVHRUUCFGRFIF-MDEJGZGSSA-N

InChI

1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

SMILES string

CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6

assay

≥99.0% (HPLC)

form

solid

optical activity

[α]20/D −123±3°, c = 1% in chloroform

quality

crystallized

mp

~265 °C (dec.)

Gene Information

human ... SLC18A2(6571)

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相关类别

Application

利血平已被用作性能研究中的测试化学物质。

Biochem/physiol Actions

利血平用于治疗妊娠期高血压（hypertensive pregnancy difficulties）。这种药物也是一种抗精神病药和降压药，可调节高血压。
抑制儿茶酚胺和血清素的囊泡摄取。

General description

利血平是一种吲哚生物碱，它不可逆地结合囊泡单胺转运蛋白VMAT1和VMAT2。它是一种可用于治疗系统性高血压的抗交感神经药物。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3

target_organs

Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF7516V
WXBF6130V
WXBF4863V
WXBF4430V
WXBF1136V

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