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Merck
CN

83580

Sigma-Aldrich

利血平

crystallized, ≥99.0% (HPLC)

别名:

(3β, 16β, 17α, 18β, 20α)-11,17-二甲氧基-18-[(3,4,5-三甲氧基苯甲酰基)氧基]育亨烷-16-羧酸甲酯

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About This Item

经验公式(希尔记法):
C33H40N2O9
CAS号:
分子量:
608.68
Beilstein:
102014
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

方案

≥99.0% (HPLC)

表单

solid

旋光性

[α]20/D −123±3°, c = 1% in chloroform

质量

crystallized

mp

~265 °C (dec.)

SMILES字符串

CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6

InChI

1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

InChI key

QEVHRUUCFGRFIF-MDEJGZGSSA-N

基因信息

human ... SLC18A2(6571)

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一般描述

利血平是一种吲哚生物碱,它不可逆地结合囊泡单胺转运蛋白VMAT1和VMAT2。它是一种可用于治疗系统性高血压的抗交感神经药物。

应用

利血平已被用作性能研究中的测试化学物质。

生化/生理作用

利血平用于治疗妊娠期高血压(hypertensive pregnancy difficulties)。这种药物也是一种抗精神病药和降压药,可调节高血压。
抑制儿茶酚胺和血清素的囊泡摄取。

象形图

Health hazardExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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