S6317
L-萝卜硫素
≥95% (HPLC), Nrf/Keap activator, oil
别名:
(R)-1-异硫氰酸基-4-（甲亚磺酰基）-丁烷, 4-甲基亚磺酰基丁基异硫氰酸酯
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关于此项目
经验公式（希尔记法）:
C6H11NOS2
化学文摘社编号:
分子量:
177.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
L-萝卜硫素, ≥95% (HPLC), oil
SMILES string
CS(=O)CCCCN=C=S
InChI key
SUVMJBTUFCVSAD-SNVBAGLBSA-N
InChI
1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3/t10-/m1/s1
assay
≥95% (HPLC)
form
oil
optical activity
[α]/D -70 to -90°, c = 1.0 in chloroform-d
color
light yellow
solubility
DMSO: >5 mg/mL
storage temp.
−20°C
Quality Level
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相关类别
Application
L-萝卜硫素可用于研究小鼠原代前脂肪细胞6和小鼠巨噬细胞RAW 264.7细胞系 中Nrf2介导的信号转导。7
Biochem/physiol Actions
L-萝卜硫素是II期解毒酶的有效选择性诱导剂，且具有抗癌特性。在十字花科蔬菜（包括西兰花）中发现的有机硫化合物。
萝卜硫素是十字花科蔬菜中的一种抗癌、抗微生物和抗糖尿病化合物。3,4 它可诱导产生解毒酶，例如引起异生素转化的醌还原酶和谷胱甘肽S-转移酶。萝卜硫素还可增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性。它通过抑制LPS介导的iNOS、COX-2、IL-1β和TNF-α.的表达来调节炎症反应。3,5
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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