所有图片(2)
About This Item
经验公式（希尔记法）:
C32H43NO4
CAS号:
分子量:
505.69
MDL编号:
UNSPSC代码:
12352205
PubChem化学物质编号:
NACRES:
NA.25
质量水平
检测方案
≥98% (HPLC)
形式
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key
WPTTVJLTNAWYAO-KPOXMGGZSA-N
基因信息
human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)
一般描述
CDDO-Me 是一种合成的三萜类化合物，具有抗炎、抗肿瘤和细胞保护作用。它来源于天然产物齐墩果酸。
应用
CDDO甲酯（甲基巴多索隆）已用于在肝脏缺血再灌注损伤(IRI)中检测其对肝细胞膜转运蛋白(HMT)的调控和对胆汁淤积症的缓解作用。它也作为NF E2相关因子2(NRF2)的激活剂，用于研究其防止黑色素瘤细胞死亡的作用。
生化/生理作用
CDDO-Me可抑制炎症介质，如白介素-6(IL-6)、IL-10和IL-12。它可增强TNF和化疗试剂诱导的细胞凋亡。CDDO-Me具有抗骨肉瘤细胞增殖活性，通过激活内源性线粒体依赖型细胞凋亡通路，可增强化疗试剂的有效性。它可作为进展型和致死型前列腺癌的辅助治疗手段。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
Tran T A, et al.
Journal of Neuroinflammation, 5(1), 1-1 (2008)
Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma.
Sandhya Chipurupalli et al.
Frontiers in oncology, 10, 758-758 (2020-06-02)
Melanoma is the most aggressive type of skin cancer and resistance to the conventional chemotherapy is the major cause for its poor prognosis. Metabolic perturbations leading to increased production of reactive oxygen species activate NRF2-dependent anti-oxidative responses to survive oxidative
A synthetic triterpenoid, CDDO-Me, inhibits IKBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor KB?regulated gene products in human leukemic cells.
Shishodia S, et al.
Clinical Cancer Research, 12(6), 1828-1838 (2006)
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
Eitas T K, et al.
PLoS ONE, 12(9), e0184164-e0184164 (2017)
Joohyun Kim et al.
Transplantation direct, 6(8), e584-e584 (2020-08-09)
Cholestasis is a sign of hepatic ischemia-reperfusion injury (IRI), which is caused by the dysfunction of hepatocyte membrane transporters (HMTs). As transcriptional regulation of HMTs during oxidative stress is mediated by nuclear factor erythroid 2-related factor 2, we hypothesized that
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