跳转至内容

尊敬的客户:

目前国际形势复杂多变,关税政策尚不明朗,这可能对我们的产品价格产生一定影响。在此情况下,我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性,如果您选择在此期间下单,我们将保留根据实际情况调整价格的权利。同时,我们也理解市场变化可能给您带来的困扰,因此如果在订单实际发货前因关税政策变动导致价格出现较大波动,默克将与您进行协商讨论并视情况对订单进行调整或取消。

Merck
CN

SMB00376

Sigma-Aldrich

CDDO 甲酯

≥98% (HPLC)

别名:

2-氰基-3,12-二氧代 - 油酸-1,9(11)-二烯-28-酸甲酯, CDDO-Me, 甲基巴多索隆

登录查看公司和协议定价

选择尺寸

5 EA
¥2,383.14

¥2,383.14


请联系客服了解存货情况

获取大包装报价

选择尺寸

变更视图
5 EA
¥2,383.14

About This Item

经验公式(希尔记法):
C32H43NO4
分子量:
505.69
MDL编号:
UNSPSC代码:
12352205
PubChem化学物质编号:
NACRES:
NA.25

¥2,383.14


请联系客服了解存货情况

获取大包装报价

质量水平

方案

≥98% (HPLC)

表单

powder

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

−20°C

SMILES字符串

CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O

InChI

1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1

InChI key

WPTTVJLTNAWYAO-KPOXMGGZSA-N

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
232012320623207
material

red polypropylene rack

material

red polypropylene rack

material

red polypropylene rack

material

red polypropylene rack

compatibility

for use with 17 mm diameter vial (90 vials per rack)

compatibility

for use with 21-23 mm diameter vial (36 vials per rack)

compatibility

for use with 29 mm diameter vial (50 vials per rack)

compatibility

for use with 11-12 mm diameter vial (50 vials per rack)

description

vial size: 7 mL

description

vial size: 15-22 mL

description

-

description

vial size: 2 mL

packaging

pkg of 5 ea

packaging

pkg of 5 ea

packaging

pkg of 5 ea

packaging

pkg of 5 ea

rack L × W × H

320 mm × 170 mm × 30 mm

rack L × W × H

320 mm × 90 mm × 30 mm

rack L × W × H

336 mm × 175 mm × 30 mm

rack L × W × H

192 mm × 100 mm × 23 mm

一般描述

CDDO-Me 是一种合成的三萜类化合物,具有抗炎、抗肿瘤和细胞保护作用。[1]它来源于天然产物齐墩果酸。[2]

应用

CDDO甲酯(甲基巴多索隆)已用于在肝脏缺血再灌注损伤(IRI)中检测其对肝细胞膜转运蛋白(HMT)的调控和对胆汁淤积症的缓解作用。[3]它也作为NF E2相关因子2(NRF2)的激活剂,用于研究其防止黑色素瘤细胞死亡的作用。[4]

生化/生理作用

CDDO-Me可抑制炎症介质,如白介素-6(IL-6)、IL-10和IL-12。它可增强TNF和化疗试剂诱导的细胞凋亡。[5]CDDO-Me具有抗骨肉瘤细胞增殖活性,通过激活内源性线粒体依赖型细胞凋亡通路,可增强化疗试剂的有效性。它可作为进展型和致死型前列腺癌的辅助治疗手段。[5]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
Tran T A, et al.
Journal of Neuroinflammation, 5(1), 1-1 (2008)
A synthetic triterpenoid, CDDO-Me, inhibits IKBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor KB?regulated gene products in human leukemic cells.
Shishodia S, et al.
Clinical Cancer Research, 12(6), 1828-1838 (2006)
Sandhya Chipurupalli et al.
Frontiers in oncology, 10, 758-758 (2020-06-02)
Melanoma is the most aggressive type of skin cancer and resistance to the conventional chemotherapy is the major cause for its poor prognosis. Metabolic perturbations leading to increased production of reactive oxygen species activate NRF2-dependent anti-oxidative responses to survive oxidative
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
Eitas T K, et al.
PLoS ONE, 12(9), e0184164-e0184164 (2017)
Joohyun Kim et al.
Transplantation direct, 6(8), e584-e584 (2020-08-09)
Cholestasis is a sign of hepatic ischemia-reperfusion injury (IRI), which is caused by the dysfunction of hepatocyte membrane transporters (HMTs). As transcriptional regulation of HMTs during oxidative stress is mediated by nuclear factor erythroid 2-related factor 2, we hypothesized that

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持