SML3844
Iberin
≥97% (NMR)
别名:
1-Isothiocyanato-3-(methylsulfinyl)propane, 3-Methylsulfinylpropyl isothiocyanate, NSC 321801
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关于此项目
经验公式（希尔记法）:
C5H9NOS2
化学文摘社编号:
分子量:
163.26
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
[S](=O)(CCCN=C=S)C
InChI key
LELAOEBVZLPXAZ-UHFFFAOYSA-N
assay
≥97% (NMR)
form
liquid
color
colorless to yellow
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Iberin is a natural isothiocyanates from cruciferous vegetables (cabbage, red cabbage, horseradish) that potently inhibits toll-like receptors (TLRs) signaling. Iberin covalently binds to TLR4 and TLR2, which inhibits TLR dimerization. Iberin exhibits potent antioxidant, anticancer, and antimicrobial activities. It is quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa through downregulation of the Gac/Rsm QS network.
Inhibits toll-like receptors (TLRs); natural isothiocyanates from cruciferous vegetables
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Composition of the Gut Microbiome Influences Production of Sulforaphane-Nitrile and Iberin-Nitrile from Glucosinolates in Broccoli Sprouts
Nutrients, 13(9), 3013-3013 (2021)
Mi-Ok Ko et al.
Journal of microbiology and biotechnology, 26(12), 2036-2042 (2016-09-03)
We evaluated the potentials of 10 isothiocyanates (ITCs) from cruciferous vegetables and radish root hydrolysate for inhibiting the growth of oral pathogens, with an emphasis on assessing any structure-function relationship. Structural differences in ITCs impacted their antimicrobial activities against oral
Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy, 58(11), 6648-6659 (2014)
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