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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
red
溶解性
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
CC1=C(SSC1=S)c2cnccn2
InChI
1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
InChI key
CKNAQFVBEHDJQV-UHFFFAOYSA-N
一般描述
Oltipraz是一种二硫醇衍生物，是二硫代硫酮类有机硫化合物的成员。它具有抗肿瘤，抗氧化，抗炎和放射防护的特性。 可以抵抗多种致癌物。Oltipraz可以用作抗血吸虫药。
生化/生理作用
Oltipraz 是 Nrf2 的激活剂。
Oltipraz是Nrf2的激活剂。 Nrf2（NF-E2相关因子2）是一种转录因子，可与抗氧化反应元件(ARE) 结合并激活这些基因。 Oltipraz可激活Nrf2，随后提高编码抗氧化剂和多药耐药相关蛋白的解毒基因的表达，以介导其化学预防功效。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nicholas T Longford
Statistics in medicine, 31(26), 3133-3146 (2012-04-26)
A general method of estimation with a variable observed subject to a limit of detection is introduced. It is based on extrapolation of the estimates obtained by increasing the limit of detection. Theoretical arguments support the method in some special
Z Yu et al.
Diabetologia, 54(4), 922-934 (2010-12-17)
We investigated whether oltipraz, a nuclear respiratory factor 2 alpha subunit (NRF2) activator, improves insulin sensitivity and prevents the development of obesity in mice. C57BL/6J mice were fed with a low-fat diet (10% of energy as fat), a high-fat diet
Varsha Rani et al.
Chemico-biological interactions, 295, 84-92 (2017-10-13)
Dimethylnitrosamine (DMN) is a potent hepatotoxic, carcinogenic and mutagenic compound. It induces massive liver cell necrosis and death in experimental animals. Several drugs have been tested in the past for their protective behavior against DMN toxicity. However, it is for
Ryan Holland et al.
Chemical research in toxicology, 22(8), 1427-1434 (2009-09-30)
The ability of three dithiolethione cancer chemopreventives, oltipraz 1, anetholedithione (ADT) 2, 1,2-dithiole-3-thione (D3T) 3, and the major metabolite, 4, of 1, to induce the cytoprotective enzyme NQO1 in Hepa 1c1c7 cells and the inhibition of this induction by catalase
Yoko Yagishita et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-14)
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the regulation of inflammation and cellular detoxication pathways. The contribution of the NRF2
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