O9389
奥替普拉
≥98% (HPLC), powder
别名:
1,2-二硫杂环戊烷-3-硫酮, BRN 0978110, CCRIS 4048, NSC 347901, RP 35972
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关于此项目
经验公式（希尔记法）:
C8H6N2S3
化学文摘社编号:
分子量:
226.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
264-736-6
MDL number:
产品名称
奥替普拉, ≥98% (HPLC), powder
InChI
1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
InChI key
CKNAQFVBEHDJQV-UHFFFAOYSA-N
SMILES string
CC1=C(SSC1=S)c2cnccn2
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
red
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Oltipraz 是 Nrf2 的激活剂。
Oltipraz是Nrf2的激活剂。 Nrf2（NF-E2相关因子2）是一种转录因子，可与抗氧化反应元件(ARE) 结合并激活这些基因。 Oltipraz可激活Nrf2，随后提高编码抗氧化剂和多药耐药相关蛋白的解毒基因的表达，以介导其化学预防功效。
General description
Oltipraz是一种二硫醇衍生物，是二硫代硫酮类有机硫化合物的成员。它具有抗肿瘤，抗氧化，抗炎和放射防护的特性。 可以抵抗多种致癌物。Oltipraz可以用作抗血吸虫药。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sang Geon Kim et al.
The Journal of pharmacy and pharmacology, 63(5), 627-635 (2011-04-16)
Oltipraz, a cancer chemopreventive agent, has an anticirrhotic effect in animals. A phase II trial was designed to investigate the preliminary efficacy of oltipraz therapy in liver fibrosis or cirrhosis. Of 83 patients who were randomized to receive placebo, oltipraz
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
Iida K, et al.
Cancer Research, 64(18), 6424-6431 (2004)
Alberto Izzotti et al.
Cancer prevention research (Philadelphia, Pa.), 3(1), 62-72 (2010-01-07)
We previously showed that exposure to environmental cigarette smoke (ECS) for 28 days causes extensive downregulation of microRNA expression in the lungs of rats, resulting in the overexpression of multiple genes and proteins. In the present study, we evaluated by
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia
Lam S, et al.
Journal of the National Cancer Institute, 94(13), 1001-1009 (2002)
Varsha Rani et al.
Chemico-biological interactions, 295, 84-92 (2017-10-13)
Dimethylnitrosamine (DMN) is a potent hepatotoxic, carcinogenic and mutagenic compound. It induces massive liver cell necrosis and death in experimental animals. Several drugs have been tested in the past for their protective behavior against DMN toxicity. However, it is for
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