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Merck
CN
所有图片(1)

文件

574215

Sigma-Aldrich

萝卜硫素

≥98% (UPLC), liquid, phase II detoxifying enzymes inducer, Calbiochem®

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别名:
萝卜硫素, 1-异硫氰基-4-(甲基亚硫酰基)丁烷，R,S-萝卜硫素
经验公式（希尔记法）:
C6H11NOS2
CAS号:
4478-93-7
分子量:
177.29
MDL编号:
MFCD00198068
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (UPLC)

形式

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

slight yellow

溶解性

ethanol: 10 mg/mL
DMSO: 20 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3

InChI key

SUVMJBTUFCVSAD-UHFFFAOYSA-N

一般描述

从花椰菜中分离的异硫氰酸酯，在小鼠组织和培养的小鼠肝癌细胞中作为II期解毒酶的有效诱导剂。它已被证明是预防大鼠化学诱导的乳腺肿瘤的有效药物。它还抑制与致癌物激活相关的I期细胞色素P450同功酶2E1和IA2。II期酶的诱导是通过丝裂原活化蛋白激酶（MAPK）途径介导的。
从花椰菜中分离的异硫氰酸酯，在小鼠组织和培养的小鼠肝癌细胞中作为II期解毒酶的有效诱导剂。被证明是预防化学诱导的大鼠乳腺肿瘤的有效药物。还显示出抑制与致癌物激活相关的I期细胞色素P450同功酶2E1和IA2。II期酶的诱导由丝裂原活化蛋白激酶（MAPK）途径介导。

生化/生理作用

主靶
小鼠组织和培养的小鼠肝癌细胞中II期解毒酶的有效诱导剂
产物不与ATP竞争。
可逆：否
细胞可渗透性：否

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻DMSO贮备液（-20°C）和乙醇贮备液(-70°C)。DMSO贮备溶液在-20°C下可稳定保存长达3个月，在-70°C下可稳定保存长达3个月。

其他说明

Gamet-Payrastre, L., et al. 2000.Cancer Res.60, 1426.
Yu, R., et al. 2000.J. Biol. Chem.275, 2322.
Yu, R., et al. 1999.J. Biol. Chem.274, 27545.
Barcelo, S., et al. 1998.Mutat.Res.402, 111.
Maheo, K., et al. 1997.Cancer Res.57, 3649.
Zhang, Y., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3147.
Zhang, Y., et al. 1992.Proc.Natl.Acad.Sci. USA89, 2399.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

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