所有图片(2)
About This Item
经验公式（希尔记法）:
C8H18N2O4S
CAS号:
分子量:
238.30
Beilstein:
883043
EC 号:
MDL编号:
UNSPSC代码:
12161700
NACRES:
NA.21
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![2-[4-(2-羟乙基)-1-哌嗪基]-乙磺酸 Buffer substance HEPES EMPROVE® EXPERT](/deepweb/assets/sigmaaldrich/product/images/351/602/c50c8b6f-6bcd-4751-9064-2cc5cb47d00f/640/c50c8b6f-6bcd-4751-9064-2cc5cb47d00f.jpg)
生物来源
synthetic
质量水平
表单
powder
技术
cell culture | mammalian: suitable
杂质
Endotoxin, microbial, and trace metals; tested
pH值（酸碱度）
4.7-5.3 (, )
有效pH范围
6.8-8.2
pKa (25 °C)
7.5
适用性
suitable for manufacturing use
异质活性
Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
SMILES字符串
OCCN1CCN(CC1)CCS(O)(=O)=O
InChI
1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
InChI key
JKMHFZQWWAIEOD-UHFFFAOYSA-N
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一般描述
我们用于生物制药加工的SAFC®系列优质原料经过严格的质量控制流程，配合记录文件和技术专长帮助我们的客户达到M-Clarity 计划规定的要求
M-Clarity 计划
缓冲液质量是生物制药工艺成功的关键，因为缓冲液几乎在每一个生产步骤中都是必不可少的。
我们广泛的缓冲材料产品线经过妥善管控，可根据您的需求量身定制。从低风险应用的非 GMP 等级，到高风险应用的 IPEC-PQG GMP标准，我们的产品可满足您的所有制造需求。
M-Clarity 计划
缓冲液质量是生物制药工艺成功的关键，因为缓冲液几乎在每一个生产步骤中都是必不可少的。
我们广泛的缓冲材料产品线经过妥善管控，可根据您的需求量身定制。从低风险应用的非 GMP 等级，到高风险应用的 IPEC-PQG GMP标准，我们的产品可满足您的所有制造需求。
应用
HEPES是一种生物缓冲液，通常被称为“好”缓冲液。它是最常用的生物缓冲液，因为HEPES的pKa为7.31，与生理pH值7.36相对应。HEPES被认为是对培养细胞系无毒的一种物质，高度可溶于水并可为溶液提供高澄清度。
HEPES用于细胞培养基、生物制药缓冲制剂(上游和下游)以及诊断试剂。基于HEPES的缓冲液被用于纯化抗体、生物活性物质、蛋白质和生长因子的生物过程。
HEPES用于细胞培养基、生物制药缓冲制剂(上游和下游)以及诊断试剂。基于HEPES的缓冲液被用于纯化抗体、生物活性物质、蛋白质和生长因子的生物过程。
法律信息
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
替代产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Brendan M Leung et al.
Journal of tissue engineering and regenerative medicine, 9(11), 1247-1258 (2013-03-19)
Modular cardiac tissues developed both vascular and cardiac structures in vivo, provided that the host response was attenuated by omitting xenoproteins from the modules. Collagen gel modules (with Matrigel(TM)) containing cardiomyocytes (CMs) alone or CMs with surface-seeded endothelial cells (ECs; CM/EC
P Dey et al.
Oncogene, 33(33), 4213-4225 (2013-10-01)
Estrogen receptor β (ERβ) is emerging as a critical factor in understanding prostate cancer biology. Although reduced in prostate cancer above Gleason grade 3, ERβ is a potential drug target at the initial stage of the disease. In human prostate
Frédéric Perros et al.
Journal of the American College of Cardiology, 65(7), 668-680 (2015-02-14)
Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting vasoconstriction, smooth muscle proliferation, and inflammation. This study sought to test the hypothesis that nebivolol, a β1-antagonist and β2,3-agonist, may improve PAH and
Alexandre Albanese et al.
ACS nano, 8(6), 5515-5526 (2014-05-07)
A nanoparticle's physical and chemical properties at the time of cell contact will determine the ensuing cellular response. Aggregation and the formation of a protein corona in the extracellular environment will alter nanoparticle size, shape, and surface properties, giving it
Suganthi Chittaranjan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(12), 3159-3173 (2014-04-12)
Triple-negative breast cancers (TNBC) are defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (ERBB2/HER2). Although initially responsive to chemotherapy, most recurrent TNBCs develop resistance, resulting in disease progression.
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