所有图片(1)
About This Item
经验公式（希尔记法）:
C28H22Cl3NO4
CAS号:
分子量:
542.84
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
质量水平
检测方案
≥97% (HPLC)
形式
powder
储存条件
desiccated
颜色
white
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC(C)c1onc(c1COc2ccc(\C=C\c3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl
InChI
1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+
InChI key
BYTNEISLBIENSA-MDZDMXLPSA-N
一般描述
GW4064是合成异恶唑，用于揭示类法尼醇X受体（FXR）的细胞结构和生理功能。是雌激素受体相关受体（ERR）激动剂。
应用
GW4064用于：
- 研究其保护小鼠肝脏免受脂多糖（LPS）诱导炎症和细胞凋亡影响的能力
- 研究其抑制脂多糖（LPS）引起回肠粘膜损伤的能力
- 处理回肠外植体
生化/生理作用
GW4064 是一种 FXR 激动剂。GW4064 是孤儿核受体 FXR 的强效 (EC50 = 15 nM) 非甾体激动剂。它对其他核受体（包括高达1 mM 的 RAR）没有活性，是研究 FXR 参与多种生物活动的重要工具。
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein-Coupled Receptors
Singh N, et al.
Molecular Endocrinology, 28(5), 659-673 (2014)
Xiang Jiang et al.
Journal of autoimmunity, 90, 64-75 (2018-02-13)
Mucosal-associated invariant T (MAIT) cells are novel innate-like T cells constituting a significant proportion of circulating and hepatic T cells. Herein, we extensively examine the phenotypical and functional alterations of MAIT cells and their regulation in a cohort of 56
Sarah Farr et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(4), G682-G693 (2020-02-01)
Postprandial dyslipidemia is a common feature of insulin-resistant states and contributes to increased cardiovascular disease risk. Recently, bile acids have been recognized beyond their emulsification properties as important signaling molecules that promote energy expenditure, improve insulin sensitivity, and lower fasting
Esther M Verhaag et al.
PloS one, 11(3), e0149782-e0149782 (2016-03-08)
Cholestasis is characterized by accumulation of bile acids and inflammation, causing hepatocellular damage. Still, liver damage markers are highest in acute cholestasis and drop when this condition becomes chronic, indicating that hepatocytes adapt towards the hostile environment. This may be
GW4064 attenuates lipopolysaccharide-induced hepatic inflammation and apoptosis through inhibition of the Toll-like receptor 4-mediated p38 mitogen-activated protein kinase signaling pathway in mice
Liu HM, et al.
International Journal of Molecular Medicine, 41(3), 1455-1462 (2018)
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