G5172
GW4064
≥97% (HPLC), farnesoid X receptor agonist, powder
别名:
3-（2,6-二氯苯基）-4-（3′-羧基-2-氯代二苯乙烯-4-基）氧甲基-5-异丙基异恶唑
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关于此项目
经验公式（希尔记法）:
C28H22Cl3NO4
化学文摘社编号:
分子量:
542.84
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
GW4064, ≥97% (HPLC)
SMILES string
CC(C)c1onc(c1COc2ccc(\C=C\c3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl
InChI
1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+
InChI key
BYTNEISLBIENSA-MDZDMXLPSA-N
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
General description
GW4064是合成异恶唑，用于揭示类法尼醇X受体（FXR）的细胞结构和生理功能。是雌激素受体相关受体（ERR）激动剂。
Application
GW4064用于：
- 研究其保护小鼠肝脏免受脂多糖（LPS）诱导炎症和细胞凋亡影响的能力
- 研究其抑制脂多糖（LPS）引起回肠粘膜损伤的能力
- 处理回肠外植体
Biochem/physiol Actions
GW4064 是一种 FXR 激动剂。
GW4064 是一种 FXR 激动剂。GW4064 是孤儿核受体 FXR 的强效 (EC50 = 15 nM) 非甾体激动剂。它对其他核受体（包括高达1 mM 的 RAR）没有活性，是研究 FXR 参与多种生物活动的重要工具。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Xiang Jiang et al.
Journal of autoimmunity, 90, 64-75 (2018-02-13)
Mucosal-associated invariant T (MAIT) cells are novel innate-like T cells constituting a significant proportion of circulating and hepatic T cells. Herein, we extensively examine the phenotypical and functional alterations of MAIT cells and their regulation in a cohort of 56
Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein-Coupled Receptors
Singh N, et al.
Molecular Endocrinology, 28(5), 659-673 (2014)
Qixiao Zhai et al.
Food & function, 10(3), 1455-1464 (2019-02-16)
The management of lead (Pb) exposure and toxicity remains a major public health priority worldwide. In our previous study, the probiotic strain Lactobacillus plantarum CCFM8661 prevented Pb absorption in mice via intestinal sequestration. This follow-up study aimed to evaluate the
GW4064 attenuates lipopolysaccharide-induced hepatic inflammation and apoptosis through inhibition of the Toll-like receptor 4-mediated p38 mitogen-activated protein kinase signaling pathway in mice
Liu HM, et al.
International Journal of Molecular Medicine, 41(3), 1455-1462 (2018)
Jing Yang et al.
Frontiers in pharmacology, 8, 260-260 (2017-05-26)
Triptolide (TP), a diterpenoid isolated from
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