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Merck
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安全信息

15205

Sigma-Aldrich

杀稻瘟素S 盐酸盐

别名:

杀稻瘟菌素S

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About This Item

经验公式（希尔记法）:
C17H26N8O5 · HCl
CAS号:
3513-03-9
分子量:
458.90
MDL编号:
MFCD02091640
UNSPSC代码:
51101500
PubChem化学物质编号:
57647341
NACRES:
NA.76

形式

powder

质量水平

200

颜色

white to off-white

溶解性

acetic acid: water: soluble, clear, colorless

抗生素抗菌谱

fungi

应用

agriculture
environmental

作用机制

protein synthesis | interferes

运输

dry ice

储存温度

−20°C

SMILES字符串

Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N

InChI

1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1

InChI key

YQXYQOXRCNEATG-ZAYJLJTISA-N

相关类别

一般描述

化学结构：核苷
杀稻瘟素S属于抗生素的氨酰基核苷类。它抑制细菌和真核生物中的蛋白质合成。它还具有杀真菌特性，可预防稻瘟病。

应用

杀稻瘟菌素 S 用作含有抗性基因 bls、bsr 或 BSD 的转化细胞的选择剂。 杀稻瘟菌素 S 已用于选择具有 TLR-2 构建体的 HEK293-T 细胞和 HEK-D5 细胞。 也用于研究肽键形成水平上的蛋白质合成。

生化/生理作用

杀稻瘟素S抑制释放因子诱导的肽基tRNA水解。它增强了tRNA与核糖体大亚基的结合，并在一定程度上抑制了肽键的形成。

包装

无底玻璃瓶。内含物装在锥底内插管中。

其他说明

保存于密闭容器内，置于干燥通风处。置于干燥处保存。储存类别（TRGS 510）：不可燃，急性毒性类别 1 和 2 /剧毒有害物质

相关产品

产品编号
说明
价格

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 1 Oral

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Product 15205, Blasticidine S hydrochloride, soluble in?

    Blasticidine S hydrochloride should be soluble in water at a concentration of 5 - 10 mg/mL. It is also soluble in acetic acid (concentration not reported).

  4. How should aqueous solutions of Product 15205, Blasticidine S hydrochloride, be stored?

    Aqueous solutions of Blasticidine S hydrochloride should be stored in aliquots at -20°C.  Aqueous solutions at a pH < 7 are stable for 1 to 2 weeks at +4°C or for 6 to 8 weeks at -20°C.  Avoid alkaline pH, and do not subject solutions to freeze-thaw cycles.

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Zhihua Chen et al.
Development (Cambridge, England), 147(18) (2020-09-09)
The central nervous system (CNS) contains a complex network of blood vessels that promote normal tissue development and physiology. Abnormal control of blood vessel morphogenesis and maturation is linked to the pathogenesis of various neurodevelopmental diseases. The CNS-specific genes that
Rohini Garg et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 5980-5987 (2010-05-05)
Vi capsular polysaccharide is a major virulence determinant of the human typhoid- causing pathogen Salmonella typhi; it is absent in nontyphoidal Salmonella serovars. We show in this study that through its specific interaction with the membrane recognition complex containing the
James M Burke et al.
Molecular cell, 75(6), 1203-1217 (2019-09-09)
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits translation initiation through eIF2α phosphorylation, which triggers stress granule (SG) formation and promotes translation of
Elizabeth J Meredith et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(36), 13485-13490 (2006-08-30)
Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and related, potentially therapeutic compounds. Proliferating normal lymphocytes and dividing malignant
Egor Svidritskiy et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12283-12288 (2013-07-05)
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine
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