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Merck
CN

D1692

Sigma-Aldrich

GW4869

≥90% (NMR), powder, N-SMase inhibitor

别名:

N,N′-双[4-(4,5-二氢-1H-咪唑-2-基)苯基]-3,3′-苯双丙烯酰胺 二盐酸盐

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About This Item

经验公式(希尔记法):
C30H28N6O2 · 2HCl
CAS号:
分子量:
577.50
UNSPSC代码:
41121800
PubChem化学物质编号:
NACRES:
NA.77

产品名称

GW4869, ≥90% (NMR)

质量水平

方案

≥90% (NMR)

表单

powder

储存条件

desiccated
protect from light

颜色

light yellow to yellow

mp

>300 °C

溶解性

DMSO: 0.2 mg/mL

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES字符串

Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3

InChI

1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5-,16-6-;;

InChI key

NSFKAZDTKIKLKT-LOLTXFFGSA-N

一般描述

GW4869是一种常用的抑制外泌体生成的药物。它阻止神经酰胺介导的多泡体(MVBs)向内出芽和成熟外泌体从MVBs释放。GW4869对表达磷脂酰丝氨酸的骨髓瘤细胞具有细胞毒性。它通过浆细胞样树突状细胞(pDCs)而抑制干扰素(干扰素)-α的分泌。

应用

GW4869已可用于:
  • 作为中性鞘磷脂酶和外泌体生物发生的抑制剂
  • 分析三氧化二砷(ATO)治疗肝癌HCCLM3细胞对神经酰胺生成的影响
  • 检测p75神经营养素受体(p75NTR)和原肌球蛋白受体激酶A (TrkA)-偶联通路对神经生长因子(NGF)诱导的大鼠热超敏的影响

生化/生理作用

N-SMase(中性鞘磷脂酶)的一种细胞渗透性、强效、特异性、非竞争性抑制剂

特点和优势

该化合物由 GlaxoSmithKline开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表,请单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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