产品名称
杀稻瘟菌素S现配溶液, Ready Made Solution, 10 mg/mL (20 mM HEPES)
SMILES string
CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
InChI key
YQXYQOXRCNEATG-UHFFFAOYSA-N
InChI
1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H
Quality Level
assay
≥98% (HPLC)
form
liquid
ready-to-use solution
concentration
10 mg/mL (20 mM HEPES)
color
colorless to faint yellow
antibiotic activity spectrum
fungi
mode of action
protein synthesis | interferes
storage temp.
−20°C
Application
杀稻瘟素S已用于：
- 研究杀真菌特性，以及预防稻瘟病。
- 用作含有抗性基因bls、bsr或bsd的转化细胞的选择剂。杀稻瘟素S已用于选择具有TLR-2构建体的HEK293-T细胞和HEK-D5细胞。
- 用于研究肽键形成水平上的蛋白质合成。
Biochem/physiol Actions
作用机制： 它抑制细菌和真核生物中的蛋白质合成。杀稻瘟素S抑制释放因子诱导的肽基tRNA水解。它增强了tRNA与核糖体大亚基的结合，并在一定程度上抑制了肽键的形成。
抗微生物谱：抗革兰氏阳性菌和革兰氏阴性菌活性。
抗微生物谱：抗革兰氏阳性菌和革兰氏阴性菌活性。
Features and Benefits
- 适合多种研究应用的高质量抗生素
- 非常适合细胞生物学和生化研究。
General description
Blasticidin S最初分离自稻瘟菌，是一种具有抗菌和杀真菌活性的细菌代谢物。该化合物是一种有效的蛋白质合成抑制剂，对多种微生物有活性，包括细菌（枯草芽孢杆菌、黄体葡萄球菌、大肠杆菌、荧光假单胞菌和结核分枝杆菌）、肿瘤细胞系和线虫。
研究中，Blasticidin S已成为一种有价值的工具，特别是作为菌株操作的标记。最近的应用包括使用囊胚杀虫素S作为携带具有囊胚杀虫素抗性的质粒的细胞的选择剂。该抗性由杀胚素S脱氨酶基因（蜡样芽孢杆菌的bsr或土曲霉的BSD）介导。这些基因产生酶，催化杀胚素S中胞嘧啶部分的水解脱胺，从而形成无毒的脱胺羟基衍生物。这种抗性机制对于细胞生物学和生物化学研究中涉及基因操作和选择的各种研究至关重要。
研究中，Blasticidin S已成为一种有价值的工具，特别是作为菌株操作的标记。最近的应用包括使用囊胚杀虫素S作为携带具有囊胚杀虫素抗性的质粒的细胞的选择剂。该抗性由杀胚素S脱氨酶基因（蜡样芽孢杆菌的bsr或土曲霉的BSD）介导。这些基因产生酶，催化杀胚素S中胞嘧啶部分的水解脱胺，从而形成无毒的脱胺羟基衍生物。这种抗性机制对于细胞生物学和生物化学研究中涉及基因操作和选择的各种研究至关重要。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
农药列管产品
此项目有
Martha Triantafilou et al.
PloS one, 8(4), e61199-e61199 (2013-04-18)
Ureaplasma species are the most frequently isolated microorganisms inside the amniotic cavity and have been associated with spontaneous abortion, chorioamnionitis, premature rupture of the membranes (PROM), preterm labour (PL) pneumonia in neonates and bronchopulmonary dysplasia in neonates. The mechanisms by
Egor Svidritskiy et al.
Journal of molecular biology, 430(5), 591-593 (2018-01-26)
Understanding the mechanisms of inhibitors of translation termination may inform development of new antibacterials and therapeutics for premature termination diseases. We report the crystal structure of the potent termination inhibitor blasticidin S bound to the ribosomal 70S•release factor 1 (RF1)
Suneesh Kumar Pachathundikandi et al.
PloS one, 6(5), e19614-e19614 (2011-05-17)
Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein. However, mechanisms of sensing this pathogen
Kamila Stokowa-Sołtys et al.
Journal of inorganic biochemistry, 127, 73-78 (2013-07-25)
Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. It is widely used to control rice blast by foliar application
Egor Svidritskiy et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12283-12288 (2013-07-05)
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine
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